a study on Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for lymphoblastic lymphoma.
PURPOSE: This randomized phase III trial is studying different regimens of combination chemotherapy to compare how well they work in treating children or adolescents with newly diagnosed stage III or stage IV lymphoblastic lymphoma.
Randomized Phase III Study for the Treatment of Newly Diagnosed Disseminated Lymphoblastic Lymphoma or Localized Lymphoblastic Lymphoma
NOTE: *All patients as of 4/2006 receive treatment on Arm III regimen only
OUTLINE: Patients are stratified by disease characteristics (disseminated lymphoblastic lymphoma vs localized lymphoblastic lymphoma [localized lymphoblastic lymphoma is closed to accrual as of 10/2005]) and age. Patients with CNS negative disseminated lymphoblastic lymphoma are randomized to 1 of 4 treatment arms*. Patients with testicular involvement at diagnosis are nonrandomly assigned to arm IV and do not receive testicular radiotherapy. Patients with localized lymphoblastic lymphoma (closed to accrual as of 10/2005) are not randomized.
NOTE: *All patients as of 4/2006 receive treatment on Arm III only
Patients are followed monthly for one year, every 3 months for 1 year, every 6 months for 1.5 years, and then annually thereafter.
PROJECTED ACCRUAL: Approximately 250-400 patients will be accrued for this study within 5 years.
Lymphoma stage III childhood lymphoblastic lymphoma stage IV childhood lymphoblastic lymphoma Methotrexate Cytarabine 6-Mercaptopurine Thioguanine Doxorubicin BB 1101 Daunorubicin Cyclophosphamide Liposomal doxorubicin Prednisone Dexamethasone Vincristine Asparaginase Dexamethasone acetate Dexamethasone 21-phosphate Calcium, Dietary Leucovorin Levoleucovorin
For people ages 1 year to 30 years
PRIOR CONCURRENT THERAPY:
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