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Summary

for females ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:

Description

Summary

The purpose of this study is to find out what effect the postoperative combination of therapies: trastuzumab (herceptin) and paclitaxel (taxol) will have on breast cancer recurrence. A combination of trastuzuamb and chemotherapy has been used in women with node positive and high risk node negative disease. This tests utilizes a well tolerated regimen of weekly paclitaxel and trastuzumab in women with T1, node negative tumors that are HER2 positive. We would like to determine how effective this drug combination is when used in women with early stage breast cancer, as well as to better define the side effects of this treatment.

Official Title

A Phase II Trial of Adjuvant Paclitaxel and Trastuzumab for Node-Negative HER2-Positive Breast Cancer

Details

  • Participants will enroll in this study at the time they are starting their adjuvant therapy for breast cancer. Participants will receive chemotherapy with paclitaxel every week for 12 weeks. They will begin to receive trastuzumab at the same time they begin paclitaxel. Once they have completed the 12 weeks of paclitaxel and trastuzumab, they will receive trastuzumab every 3 weeks or weekly for 40 weeks.
  • Participants will be followed with routine assessments such as physical exam and vital signs every 3 months for the first year, and then every 6 months for years 2-5. Then we would like to keep track of the participants medical condition by calling them on the telephone once per year.

Keywords

Breast Cancer Carcinoma of the Breast node-negative breast cancer HER-2 positive Breast Neoplasms Paclitaxel Albumin-Bound Paclitaxel Trastuzumab

Eligibility

You can join if…

Open to females ages 18 years and up

  • Histologically confirmed invasive carcinoma of the breast
  • Tumors must be less than or equal to 3cm in greatest dimension
  • Must have node-negative breast cancer according to teh AJCC 7th edition
  • ER/PR determination is required. ER- and PR-assays should be performed by immunohistochemical methods
  • HER-2 positive: IHC 3+ or FISH >2
  • Bilateral breast cancers that individually meet eligibility criteria are allowed
  • Patients should have tumor tissue available, and a tissue block of sufficient size to make 15 slides must be sent to DFCI for testing
  • Less than or equal to 84 days from mastectomy or from axillary dissection or sentinel node biopsy if the patient's most extensive breast surgery was a breast-sparing procedure
  • All tumor should be removed by either a modified radical mastectomy or a segmental mastectomy (lumpectomy), with either a sentinel node biopsy or axillary dissection
  • 18 years of age or older
  • ECOG Performance Status of 0 or 1
  • Adequate bone marrow function, hepatic function, and renal function as outlined in protocol
  • Left ventricular ejection fraction of greater than or equal to 50%
  • Willingness to discontinue any hormonal agent prior to registration and while on study
  • Willingness to discontinue sex hormonal therapy, e.g. birth control pills, prior to registration and while on study
  • Patients with a history of ipsilateral DCIS are eligible if they were treated with wide-excision alone, without radiation therapy
  • Patients undergoing breast conservation therapy must not have any contraindications to radiation therapy

You CAN'T join if...

  • Pregnant or nursing women
  • Locally advanced tumors at diagnosis, including tumors fixed to the chest wall, peau d'orange, skin ulcerations/nodules, or clinical inflammatory changes
  • History of prior chemotherapy in past 5 years
  • History of prior trastuzumab therapy
  • Active, unresolved infection
  • Prior history of any other malignancy in the past 5 years, except for early stage tumors of the skin or cervix treated with curative intent
  • Sensitivity to benzyl alcohol
  • Grade 2 or greater neuropathy per NCI's CTCAv3.0. (Exception: Any chronic neurologic disorder will be looked at on a case-by-case basis by the study chair).
  • Active cardiac disease as outlined in protocol.

Locations

  • University of California-San Francisco
    San Francisco, California, 94115, United States
  • Washington University
    St. Louis, Missouri, 63110, United States
  • Loyola University Medical Center
    Maywood, Illinois, 60153, United States
  • Indiana University
    Indianapolis, Indiana, 46202, United States
  • Tennesse Oncology
    Nashville, Tennessee, 37203, United States
  • Case Western University
    Cleveland, Ohio, 44195, United States
  • University of North Carolina at Chapel Hill
    Chapel Hill, North Carolina, 27599, United States
  • Duke Comprehensive Cancer Center
    Durham, North Carolina, 27710, United States
  • John Hopkins University
    Baltimore, Maryland, 21231, United States
  • Memorial Sloan Kettering Cancer Center
    New York, New York, 10021, United States
  • Weill Cornell Medical College
    New York, New York, 10065, United States
  • University of Vermont Cancer Center
    Burlington, Vermont, 05401, United States
  • North Shore LIJ Health System Monter Cancer Center
    Lake Success, New York, 11042, United States
  • Lowelll General Hospital
    Lowell, Massachusetts, 01854, United States
  • Dana-Farber at Faulkner Hospital
    Boston, Massachusetts, 02130, United States
  • Dana-Farber Cancer Institute
    Boston, Massachusetts, 02215, United States
  • Beth Israel Deaconess Medical Center
    Boston, Massachusetts, 02115, United States
  • Massachusetts General Hospital
    Boston, Massachusetts, 02114, United States
  • North Shore Medical Center
    Peabody, Massachusetts, 01960, United States
  • Cape Cod Healthcare
    Hyannis, Massachusetts, 02601, United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Eric Winer, MD
ID
NCT00542451
Phase
Phase 2
Lead Scientist
Hope Rugo
Study Type
Interventional
Last Updated
April 2016