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Eligibility
for people ages 18 years to 75 years
Location
at San Francisco, California
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

Details

In this study, we will explore mechanisms of exacerbation in asthma by careful characterization studies in asthmatics presenting in acute severe exacerbation. Specifically, we will determine the frequency of secretor status in these subjects by blood and saliva testing, and we will also perform a detailed cellular and biochemical analysis of their airway secretions. We will collect airway secretions using two methods. One method will be to have subjects cough sputum into a clean plastic container. The other method only applies to asthmatics with near-fatal asthma requiring intubation and mechanical ventilation. In these asthmatics, we will collect airway secretions by tracheal aspirate using methods normally applied in their clinical care.

Keywords

Asthma

Eligibility

You can join if…

Open to people ages 18 years to 75 years

  1. Male and female subjects with a history of asthma between the ages of 18 to 75 years.
  2. Physician diagnosis of asthma.
  3. Currently experiencing an acute exacerbation of asthma. This exacerbation may be severe necessitating treatment in the emergency room, ICU, or hospital ward.
  4. Ability to provide informed consent.

You CAN'T join if...

  1. Lung disease other than asthma.
  2. Females who are lactating or who are pregnant.
  3. Use of recreational drugs in the 1 month preceding the study.

Location

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
Links
UCSF Airway Clinical Research Center website
ID
NCT00594750
Lead Scientist
John Fahy
Study Type
Observational
Last Updated
June 2016
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