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for people ages 22–89 (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



The purpose of this study is to better understand why some vein bypass grafts develop narrowing. Evidence suggests that there is a relationship between inflammatory markers in the blood and the narrowing that occurs in blood vessels. In this study, we will look at inflammatory markers in the blood and how well the vein graft functions.


Peripheral Arterial Disease Cardiovascular Disease


You can join if…

Open to people ages 22–89

  • Age> 22 or < 90 years
  • Undergoing lower extremity (infrainguinal) bypass using autologous vein for the treatment of disabling claudication or critical limb ischemia secondary to chronic atherosclerotic occlusive disease
  • Able to understand, give, and take part in the consent process

You CAN'T join if...

  • Age < 22 or> 90 years
  • Grafts employing prosthetic or other non-autologous vein material in any part (e.g.composite grafts). [Patch angioplasty of inflow and outflow vessel permissible with any material]
  • Vasculitis, trauma, acute embolic disease as etiology of limb ischemia
  • History of diagnosed hypercoagulable state
  • Evidence of active infection - pneumonia, urinary tract, etc., requiring medical therapy
  • Evidence of significant local sepsis in foot or limb prior to bypass
  • Patients taking immunosuppressant medications (steroids, chemotherapeutic agents)
  • Other concurrent significant illness within 30 days
  • Non-English speakers



accepting new patients
Start Date
Completion Date
University of California, San Francisco
Lead Scientist
Warren Gasper
Study Type
Last Updated
April 2016