The purpose of this study is to better understand why some vein bypass grafts develop narrowing. Evidence suggests that there is a relationship between inflammatory markers in the blood and the narrowing that occurs in blood vessels. In this study, we will look at inflammatory markers in the blood and how well the vein graft functions.
Peripheral Arterial DiseaseCardiovascular Disease
You can join if…
Open to people ages 22–89
Age> 22 or < 90 years
Undergoing lower extremity (infrainguinal) bypass using autologous vein for the treatment of disabling claudication or critical limb ischemia secondary to chronic atherosclerotic occlusive disease
Able to understand, give, and take part in the consent process
You CAN'T join if...
Age < 22 or> 90 years
Grafts employing prosthetic or other non-autologous vein material in any part (e.g.composite grafts). [Patch angioplasty of inflow and outflow vessel permissible with any material]
Vasculitis, trauma, acute embolic disease as etiology of limb ischemia
History of diagnosed hypercoagulable state
Evidence of active infection - pneumonia, urinary tract, etc., requiring medical therapy
Evidence of significant local sepsis in foot or limb prior to bypass