The purpose of this study is to investigate whether neratinib can further reduce the risk of recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment with trastuzumab.
A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer
Breast CancerHER-2/erbB-2 positive breast canceradjuvant therapyneratinibHKI-272Trastuzumab
You can join if…
Open to females ages 18 years and up
Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.
Been treated for early breast cancer with standard of care duration of trastuzumab.
Could have been treated neoadjuvantly but have not reached pCR.
You CAN'T join if...
Positive clinical and radiologic assessments for local or regional recurrence of disease at the time of study entry.
History of heart disease.
QTc interval>0.45 seconds
History of gastrointestinal disease with diarrhea as the major symptom.
Helen Diller Family University of California San Francisco Comprehensive Cancer Center San Francisco, California, 94115, USA
Ronald Yanagihara, M.D. Gilroy, California, 95020, USA
California Cancer Care Greenbrae, California, 94904, USA
San Francisco Oncology Associates San Francisco, California, 94115, USA
Redwood Regional Medical Group Santa Rosa, California, 95403, USA
The Cancer Prevention and Treatment Center Soquel, California, 95073, USA
Cedars-Sinai Medical Group Beverly Hills, California, 90211, USA
Glendale Adventist Medical Center Cancer Services Glendale, California, 91206, USA
Beaver Medical Group, L.P. Highland, California, 92346, USA
Breastlink Medical Group Long Beach, California, 90806, USA
Long Beach Memorial Medical Center Long Beach, California, 90806, USA
Facey Medical Group Mission Hills, California, 91345, USA
Gynecologic Oncology Associates Newport Beach, California, 92663, USA
Ventura County Hematology-Oncology Specialists Oxnard, California, 93030, USA
Desert Hematology Oncology Medical Group, Inc Rancho Mirage, California, 92270, USA