RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.
PURPOSE: The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma.
A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
To collect biological specimens from patients with osteosarcoma at Children's Oncology Group (COG) institutions.
To provide a repository for long-term storage of osteosarcoma-related biological materials.
To make these specimens available to qualified researchers to understand the biology of osteosarcoma and correlate these results with the patients' clinical data.
OUTLINE: After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.
For people ages up to 120 years
All osteosarcoma patients seen at COG institutions are eligible, including the following:
Newly diagnosed patients
Patients with recurrent disease who were not enrolled at the time of diagnosis
The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:
Paraffin embedded block OR 30 unstained slides
Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
Fresh and frozen tumor specimens
PRIOR CONCURRENT THERAPY:
Patients are not required to enter a therapeutic study to enroll on this study
Children's Hospital and Research Center Oaklandaccepting new patients Oakland, California, 94609, USA
UCSF Helen Diller Family Comprehensive Cancer Centeraccepting new patients San Francisco, California, 94115, USA
Lucile Packard Children's Hospital at Stanford University Medical Centeraccepting new patients Palo Alto, California, 95798, USA
Kaiser Permanente Medical Center - Oaklandaccepting new patients Sacramento, California, 95661, USA
Loma Linda University Cancer Institute at Loma Linda University Medical Centeraccepting new patients Loma Linda, California, 92354, USA
Jonathan Jaques Children's Cancer Center at Miller Children's Hospitalaccepting new patients Long Beach, California, 90801, USA
Childrens Hospital Los Angelesaccepting new patients Los Angeles, California, 90027, USA
Southern California Permanente Medical Groupaccepting new patients Los Angeles, California, 90027, USA
Mattel Children's Hospital at UCLAaccepting new patients Los Angeles, California, 90095, USA
Children's Hospital Central Californiaaccepting new patients Madera, California, 93638, USA
Children's Hospital of Orange Countyaccepting new patients Orange, California, 92868, USA
Rady Children's Hospital - San Diegoaccepting new patients San Diego, California, 92123, USA