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Eligibility
for people ages up to 99 years
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:

Description

Summary

Congenital heart defects (CHD) are the most common major human birth malformation, affecting ~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited. The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will be recruited from the Pediatric Cardiac Genomics Consortium's (PCGC) centers of the NHLBI-sponsored Bench to Bassinet (B2B) Program. Biological specimens will be obtained for genetic analyses, and phenotype data will be collected by interview and from medical records. State-of-the-art genomic technologies will be used to identify common genetic causes of CHD and genetic modifiers of clinical outcome. To accomplish this, the PCGC will develop and maintain a biorepository of specimens (DNA) and genetic data, along with detailed, phenotypic and clinical outcomes data in order to investigate relationships between genetic factors and phenotypic and clinical outcomes in congenital heart disease.

Keywords

Congenital Heart Defects

Eligibility

You can join if…

Open to people ages up to 99 years

• Signed consent form

You CAN'T join if...

  • Isolated patent foramen ovale
  • Isolated prematurity-associated patent ductus arteriosus

Locations

  • Stanford University accepting new patients
    Palo Alto, California, 94304, United States
  • Children's Hospital Los Angeles accepting new patients
    Los Angeles, California, 90027, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Children's Hospital Medical Center, Cincinnati
Links
Click here for more information about the entire Bench to Bassinet program.
ID
NCT01196182
Study Type
Observational
Last Updated
April 1, 2017
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