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Eligibility
for people ages 18 years and up
Location
at San Francisco, California and other locations
Dates
study started

Description

Summary

This randomized phase III trial studies giving everolimus together with bevacizumab to see how well it works compared to everolimus alone in treating patients with advanced kidney cancer that progressed after first-line therapy. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can interfere with tumor growth by blocking the ability of tumor cells to grow and spread. Everolimus and bevacizumab may also stop the growth of kidney cancer by blocking blood flow to the tumor. It is not yet known whether giving everolimus together with bevacizumab is better than everolimus alone in treating patients with advanced kidney cancer that has progressed after first-line therapy.

Official Title

Randomized Phase III Trial Comparing Everolimus Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors

Details

PRIMARY OBJECTIVES:

l. To compare the overall survival of patients receiving bevacizumab plus everolimus and everolimus alone among patients with advanced renal cell carcinoma progressing after first line vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitor (TKI) treatment.

SECONDARY OBJECTIVES:

I. To compare the progression-free survival and proportion who experience an objective response (defined as complete clinical response [cCR] + partial response [PR]) in patients with advanced renal cell carcinoma receiving bevacizumab plus everolimus and everolimus alone.

II. To compare grade 3 or higher toxicity in patients receiving each treatment regimen.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive everolimus orally (PO) once daily (QD) on days 1-28.

ARM II: Patients receive everolimus PO QD on days 1-28 and bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 8 weeks until disease progression and then every 6 months for up to 5.5 years.

Keywords

Clear Cell Renal Cell Carcinoma Recurrent Renal Cell Carcinoma Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Bevacizumab Everolimus Sirolimus Endothelial Growth Factors Antibodies Immunoglobulins Antibodies, Monoclonal Immunoglobulin G

Eligibility

For people ages 18 years and up

Inclusion Criteria:

  • Renal cell carcinoma with some component of clear cell histology
  • Metastatic or unresectable disease
  • Must have been treated with at least 1 prior VEGFR tyrosine kinase inhibitor treatment and have progressed or have been intolerant to treatment
  • No prior systemic therapy with a vascular endothelial growth factor (VEGF) binding agent (e.g., bevacizumab)
  • No prior systemic therapy with any mechanistic target of rapamycin (mTOR) inhibitor(e.g., sirolimus, temsirolimus, everolimus)
  • Prior cytokine therapy is allowed
  • Any systemic therapy must be completed at least 4 weeks prior to registration
  • = 2 weeks since any prior radiation (including palliative)

  • Patients must not have had a major surgical procedure, open biopsy, or significant traumatic injury within 4 weeks prior to study registration, and must have fully recovered from any such procedure
  • The following are not considered to be major procedures: thoracentesis,paracentesis, port placement, laparoscopy, thoracoscopy, bronchoscopy,endoscopic ultrasonographic procedures, mediastinoscopy, skin biopsies,incisional biopsies and routine dental procedures
  • Patients must have measurable disease by RECIST criteria; lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as>=2 cm with conventional techniques or as>= 1 cm with spiral computed tomography (CT)scan
  • No active brain metastases: patients with treated, stable brain metastases for at least three months are eligible as long as they meet the following criteria:
  • Treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 3 months, as ascertained by clinical examination and brain imaging(magnetic resonance imaging [MRI] or CT) (stable dose of anticonvulsants are allowed); treatment for brain metastases may include whole brain radiotherapy(WBRT), radiosurgery (RS; Gamma Knife, linear accelerator [LINAC], or equivalent) or a combination as deemed appropriate by the treating physician;patients with central nervous system (CNS) metastases treated by neurosurgical resection or brain biopsy performed within 3 months prior to day 1 are not eligible
  • Baseline brain imaging (MRI/CT) is required
  • No serious non-healing wound, ulcer, or bone fracture
  • No arterial thrombotic events within 6 months of registration:
  • Including transient ischemic attack (TIA), cerebrovascular accident (CVA),peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the past 6 months, or myocardial infarction (MI);patients with clinically significant peripheral artery disease (i.e.,claudication on less than one block), significant vascular disease (i.e., aortic aneurysm, history of aortic dissection), or any other arterial thrombotic event are ineligible
  • Patients who have experienced a deep venous thrombosis or pulmonary embolus within the past 6 months must be on stable therapeutic anticoagulation to be enrolled to this study
  • Patients receiving anti-platelet agents and prophylactic anticoagulation are eligible
  • No inadequately controlled hypertension: (defined as a blood pressure of>= 160 mmHg systolic and/or>= 90 mmHg diastolic on medication), or any prior history of hypertensive crisis or hypertensive encephalopathy
  • No known severe impairment of lung function, defined as>= grade 2 dyspnea or cough,or either:
  • Requirement of supplemental oxygen, or
  • In cases where pulmonary function or pulse oximetry tests have been obtained,forced expiratory volume of the lung in one second (FEV1) or forced vital capacity (FVC) are < 50% of predicted, or single breath diffusing capacity of the lung for carbon monoxide (DLCO) is < 35% of predicted or resting room oxygen saturation is less than 90%
  • No active or severe liver disease (e.g. acute or chronic hepatitis, cirrhosis)
  • No positive serology for anti-hemoglobin C (HBC) or anti-hepatitis C virus (HCV)antibodies; hepatitis B virus (HBV) seropositive patients (hepatitis B surface antigen [HBsAg] positive) are eligible if they are closely monitored for evidence of active HBV infection by HBV deoxryribonucleic acid (DNA) testing and agree to receive suppressive therapy with lamivudine or other HBV-suppressive therapy until at least 4 weeks after the last dose of everolimus
  • No New York Heart Association (NYHA) class>= 2 congestive heart failure
  • No active bleeding or chronic hemorrhagic diathesis or increased risk for bleeding:Including but not limited to history of major bleeding within 6 months (e.g.gastrointestinal, lung, CNS sites; or required transfusion support)
  • No history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to the initiation of treatment
  • No ongoing immunosuppressive therapy: including chronic systemic treatment with corticosteroids (>= 10 mg/day prednisone equivalent)
  • Archival tissue must be available for submission: though it is optional patients to choose to participate in the correlative substudies or not
  • Patients who are pregnant or nursing are not eligible
  • Women of child bearing potential must have a negative serum or urine pregnancy test within 16 days prior to registration
  • Women of child-bearing potential include:
  • Any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea>= 12 consecutive months)
  • Women on hormone replacement therapy (HRT) with documented serum follicle stimulating hormone (FSH) level> 35m IU/mL
  • Women who are using oral, implanted or injectable contraceptive hormones or mechanical products such as an intrauterine device or barrier methods(diaphragm, condoms, spermicides) to prevent pregnancy or practicing abstinence or where partner is sterile (e.g., vasectomy)
  • Performance status Eastern Cooperative Oncology Group (ECOG) 0-2 or Karnofsky score

    = 60%

  • Granulocytes>= 1,500/μL
  • Platelet count>= 100,000/μL
  • Calculated creatinine clearance>= 30 mL/minute (modified Cockroft and Gault formula)
  • Bilirubin =< 1.5 x upper limits of normal
  • Aspartate aminotransferase (AST) =< 2.5 x upper limits of normal (ULN)
  • Fasting serum triglycerides =< 200 mg/dL
  • Serum cholesterol =< 300 mg/dL
  • Fasting serum glucose =< 1.5 x ULN
  • Urine protein to creatinine ratio < 1.0 or urine protein =< 1+

Locations

  • Kaiser Permanente-Deer Valley Medical Center
    Antioch, California, 94531, USA
  • Alta Bates Summit Medical Center-Herrick Campus
    Berkeley, California, 94704, USA
  • Mills - Peninsula Hospitals
    Burlingame, California, 94010, USA
  • East Bay Radiation Oncology Center
    Castro Valley, California, 94546, USA
  • Valley Medical Oncology Consultants-Castro Valley
    Castro Valley, California, 94546, USA
  • Bay Area Breast Surgeons Inc
    Emeryville, California, 94608, USA
  • Epic Care Partners in Cancer Care
    Emeryville, California, 94608, USA
  • Kaiser Permanente-Fremont
    Fremont, California, 94538, USA
  • Valley Medical Oncology Consultants-Fremont
    Fremont, California, 94538, USA
  • Contra Costa Regional Medical Center
    Martinez, California, 94553, USA
  • Memorial Medical Center
    Modesto, California, 95355, USA
  • El Camino Hospital
    Mountain View, California, 94040, USA
  • Sutter Cancer Research Consortium
    Novato, California, 94945, USA
  • Highland General Hospital
    Oakland, California, 94602, USA
  • Alta Bates Summit Medical Center - Summit Campus
    Oakland, California, 94609, USA
  • Bay Area Tumor Institute
    Oakland, California, 94609, USA
  • Hematology and Oncology Associates-Oakland
    Oakland, California, 94609, USA
  • Tom K Lee Inc
    Oakland, California, 94609, USA
  • Kaiser Permanente Oakland-Broadway
    Oakland, California, 94611, USA
  • Kaiser Permanente-Oakland
    Oakland, California, 94611, USA
  • Kaiser Permanente-Rancho Cordova Cancer Center
    Rancho Cordova, California, 95670, USA
  • Kaiser Permanente-Redwood City
    Redwood City, California, 94063, USA
  • Kaiser Permanente-Richmond
    Richmond, California, 94801, USA
  • Rohnert Park Cancer Center
    Rohnert Park, California, 94928, USA
  • Kaiser Permanente-Roseville
    Roseville, California, 95661, USA
  • The Permanente Medical Group-Roseville Radiation Oncology
    Roseville, California, 95678, USA
  • Kaiser Permanente-South Sacramento
    Sacramento, California, 95823, USA
  • South Sacramento Cancer Center
    Sacramento, California, 95823, USA
  • Kaiser Permanente - Sacramento
    Sacramento, California, 95825, USA
  • California Pacific Medical Center-Pacific Campus
    San Francisco, California, 94115, USA
  • Kaiser Permanente-San Francisco
    San Francisco, California, 94115, USA
  • Kaiser Permanente-Santa Teresa-San Jose
    San Jose, California, 95119, USA
  • Kaiser Permanente San Leandro
    San Leandro, California, 94577, USA
  • Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California, 94806, USA
  • Kaiser Permanente-San Rafael
    San Rafael, California, 94903, USA
  • Kaiser Permanente Medical Center - Santa Clara
    Santa Clara, California, 95051, USA
  • Kaiser Permanente-Santa Rosa
    Santa Rosa, California, 95403, USA
  • Sutter Pacific Medical Foundation
    Santa Rosa, California, 95403, USA
  • Kaiser Permanente Cancer Treatment Center
    South San Francisco, California, 94080, USA
  • Kaiser Permanente-South San Francisco
    South San Francisco, California, 94080, USA
  • Kaiser Permanente-Stockton
    Stockton, California, 95210, USA
  • Kaiser Permanente Medical Center-Vacaville
    Vacaville, California, 95688, USA
  • Kaiser Permanente-Vallejo
    Vallejo, California, 94589, USA
  • Sutter Solano Medical Center/Cancer Center
    Vallejo, California, 94589, USA
  • Kaiser Permanente-Walnut Creek
    Walnut Creek, California, 94596, USA
  • Kaiser Permanente-Anaheim
    Anaheim, California, 92807, USA
  • Kaiser Permanente-Baldwin Park
    Baldwin Park, California, 91706, USA
  • Kaiser Permanente-Bellflower
    Bellflower, California, 90706, USA
  • Kaiser Permanente Hospital
    Fontana, California, 92335, USA
  • Kaiser Permanente
    Fresno, California, 93720, USA
  • Kaiser Permanente - Harbor City
    Harbor City, California, 90710, USA
  • Kaiser Permanente-Irvine
    Irvine, California, 92618, USA
  • UC San Diego Moores Cancer Center
    La Jolla, California, 92093, USA
  • Kaiser Permanente Los Angeles Medical Center
    Los Angeles, California, 90027, USA
  • Kaiser Permanente-Cadillac
    Los Angeles, California, 90034, USA
  • Kaiser Permanente - Panorama City
    Panorama City, California, 91402, USA
  • PCR Oncology
    Pismo Beach, California, 93449, USA
  • Kaiser Permanente-Riverside
    Riverside, California, 92505, USA
  • Kaiser Permanente-San Diego Mission
    San Diego, California, 92108, USA
  • Kaiser Permanente-San Diego Zion
    San Diego, California, 92120, USA
  • Kaiser Permanente-San Marcos
    San Marcos, California, 92069, USA
  • Kaiser Permanente
    Woodland Hills, California, 91367, USA

Details

Status
in progress, not accepting new patients
Start Date
Sponsor
National Cancer Institute (NCI)
ID
NCT01198158
Phase
Phase 3
Study Type
Interventional
Last Updated
November 2016