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Summary

Eligibility
for people ages 6 years and up
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

The mission of the SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time. The ultimate goal of these efforts is to promote better treatments for severe asthma.

Details

The mission of the SARP is to improve the understanding of severe asthma to develop better treatments. The SARP will gain a better understanding of asthma and its endotypes, in children and adults, by defining the disease at the molecular and cellular levels in the context of the temporal phenotypic expression of the disease. To this end, the SARP investigators will utilize both mechanistic and evoked phenotype approaches to: 1) characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma, and 2) to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes and 3) compare these features over time. This approach involves a shared longitudinal protocol conducted across all participating centers which includes common information on all SARP participants. Additionally, the SARP investigators have each identified mechanistic research questions to be included in the shared longitudinal protocol. Together, these longitudinal and mechanistic approaches will enable prediction of phenotype stability/fluctuation and pharmacologic responses and identification of novel, disease-modifying targets for treatment.

Keywords

Asthma Severe

Eligibility

For people ages 6 years and up

Asthmatic Patients:

Inclusion Criteria:

  1. Physician diagnosis of asthma,
  2. Age 6 years and older
  3. Evidence of historical reversibility, including either:

    • FEV1 bronchodilator reversibility ≥ 12%, or
    • Airway hyperresponsiveness reflected by a methacholine PC20 ≤16 mg/mL.

Exclusion Criteria:

  1. Pregnancy during the characterization phase,
  2. Current smoking,
  3. Smoking history> 10 pack years if ≥30 years of age, or smoking history> 5 pack years if <30 years of age (Note: if a subject has a smoking history, no smoking within the past year),
  4. Other chronic pulmonary disorders associated with asthma-like symptoms, including (but not limited to) cystic fibrosis, chronic obstructive pulmonary disease, chronic bronchitis, vocal cord dysfunction (that is the sole cause of respiratory symptoms and at the PI's discretion), severe scoliosis or chest wall deformities that affect lung function, or congenital disorders of the lungs or airways,
  5. History of premature birth before 35 weeks gestation,
  6. Unwillingness to receive an intramuscular triamcinolone acetonide injection,
  7. Evidence that the participant or family may be unreliable or poorly adherent to their asthma treatment or study procedures,
  8. Planning to relocate from the clinical center area before study completion,
  9. Any other criteria that place the subject at unnecessary risk according to the judgment of the Principal Investigator and/or attending physician(s) of record, or
  10. Currently participating in an investigational drug trial for asthma therapies.

Healthy Controls:

Inclusion criteria: Healthy subjects between the age of 18 and 65 years. At least 3 of the 7 subjects per center should be aged 35 years or older.

Exclusion criteria

  1. History of chronic diseases that affect the lungs,
  2. A history suggestive of allergic rhinitis, eczema or chronic sinusitis,
  3. An improvement in FEV1 of more than 12% following 4 puffs of albuterol,
  4. Smoking history> 10 pack years if ≥30 years of age, or smoking history> 5 pack years if <30 years of age, or any smoking within the past year,
  5. Respiratory tract infection within the past 4 weeks,
  6. Pregnancy,
  7. History of premature birth (<35 weeks).

Locations

  • Washington University
    St. Louis, Missouri, 63110, United States
  • University of Wisconsin-Madison
    Madison, Wisconsin, 53792, United States
  • Emory University
    Atlanta, Georgia, 30322, United States
  • Cleveland Clinic
    Cleveland, Ohio, 44195, United States
  • Rainbow Babies and Children's Hospital, Case Western Reserve University
    Cleveland, Ohio, 44106, United States
  • University of Pittsburgh
    Pittsburgh, Pennsylvania, 15213, United States
  • Wake Forest University Health Sciences
    Winston-Salem, North Carolina, 27157, United States
  • University of Virginia Health System
    Charlottesville, Virginia, 22908-0386, United States
  • Virginia Commonwealth University
    Richmond, Virginia, 23298-0225, United States
  • Brigham & Women's Hospital
    Boston, Massachusetts, 02115, United States
  • Children's Hospital, Boston
    Boston, Massachusetts, 02115, United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Milton S. Hershey Medical Center
ID
NCT01606826
Lead Scientist
Ngoc Ly
Study Type
Observational
Last Updated
September 1, 2016