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Eligibility
for people ages 18–60
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

The goal of the proposed pilot study is to determine whether glucose control can be improved with Bydureon treatment in patients with type I diabetes (T1D)

Details

This is a multi-site randomized placebo controlled trial of Bydureon in patients with type I diabetes (T1D) of at least 2 years duration who may or may not still have detectable levels of C-peptide during a mixed meal tolerance test (MMTT). Bydureon is a recently approved long acting form of Exenatide. Because of the lack of safety data for Bydureon in children, we propose to conduct the trial in adults (>18 yrs.).

Both the subject and the study personnel will be blinded to treatment assignment. The randomization will be done, 1;1, by the coordinating site (at Yale). As a secondary analysis, we propose to determine whether the presence of residual insulin production modifies the drug effect. To do this, we plan to stratify patients for randomization on the basis of detectable C-peptide levels. We will therefore wait for the results of the C-peptide levels from the enrollment MMTT prior to randomization. The study investigators will not be told in which stratum the patient is being randomized and will be blinded to the C-peptide results of the MMTT until the conclusion of the study.

Note: The primary and study completion dates were changed 4/2016 to reflect an extension of the recruitment and accrual periods.

Keywords

Type I Diabetes Exenatide

Eligibility

You can join if…

Open to people ages 18–60

  • Male or female aged 18-60 years who meets the American Diabetes Association standard T1DM criteria.
  • Diagnosis of T1DM at least 2 years from Visit 0
  • Insulin Requirement of ≤ 0.90 units/kg
  • Absence of ketoacidosis in the past 6 months
  • HbA1c of ≤ 9.0%
  • Menstruating women must have a negative pregnancy test and be willing to avoid pregnancy during the study period
  • Signed informed consent

You CAN'T join if...

  • Inability or unwillingness to give informed consent
  • Current or prior use of immunomodulators or systemic steroids in the last 6 months that could potentially affect diabetes or immunologic status.
  • Known hypersensitivity to Exenatide, Liraglutide or any product component.
  • Participation in an investigational treatment trial within the last 6 weeks before enrollment.
  • 1 or more episodes of hypoglycemia (loss of consciousness or requiring the help of others) within the last 6 months.
  • Another condition that would, in the view of the investigator, affect the safety of using Bydureon. This might include, among others a history of MEN 2, a history of medullary carcinoma of the thyroid or pancreatitis.
  • Known severe renal impairment, end-stage renal disease or renal transplantation.
  • Any history of gastroparesis or other severe gastrointestinal disease, pancreatitis,thyroid nodules or malignancy with the exclusion of a history of localized basal cell carcinoma.
  • Uncompensated heart failure, fluid overload, myocardial infarction or liver disease within the last 6 weeks before enrollment.
  • Clinically active serious infection.
  • Positive pregnancy test in menstruating women or lactating females.
  • Concurrent use of Pramlinitide, other Incretin medications, or other anti-diabetes medications other than insulin.

Locations

  • Barbara Davis Center accepting new patients
    Aurora, Colorado, USA
  • Yale University accepting new patients
    New Haven, Connecticut, USA
  • University of Miami accepting new patients
    Miami, Florida, 33136, USA
  • University of Chicago accepting new patients
    Chicago, Illinois, USA
  • Joslin Diabetes Center accepting new patients
    Boston, Massachusetts, 02215, USA
  • University of Michigan accepting new patients
    Ann Arbor, Michigan, 48105, USA
  • SUNY Upstate Medical University accepting new patients
    Syracuse, New York, 13210, USA

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Yale University
ID
NCT01928329
Phase
Phase 2
Lead Scientist
Stephen Gitelman
Study Type
Interventional
Last Updated
December 1, 2016
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