The purpose of this study is to find out how the amount of fat or sugar in a person's diet, or the number of meals eaten each day, affect the amount of fat that people's bodies make, the types of fats in the bloodstream, and how much fat is stored in the liver. The study is funded by the National Institutes of Health.
Lipogenesis, Lipoprotein Flux, and CVD Risk: Role of Meal Composition and Frequency
The study consists of two 10-day feeding periods that are separated by approximately two weeks. During each feeding period all food and beverages to be consumed will be provided by the study.
In Study 1, participants will be randomly assigned to receive one of two diets. Both diets are designed to maintain weight at a constant level. The diets are balanced nutritionally and have the same amount of protein. One diet has higher amounts of sugar, while the other has higher amounts of fat. For one 10-day period, the diet will be fed as two large meals ('meal-feeding'). For the other 10-day period, the identical diet will be fed as 8 small meals ('nibbling'). Half of the participants will meal-feed first, while the other half will 'nibble' first. The order of nibbling or meal feeding will be determined randomly.
In Study 2, the number of meals eaten per day will remain fixed at three (no nibbling or meal feeding). Participants will receive both the diet higher in sugar and the diet higher in fat. However, they will be randomly assigned to start one followed by the other for each 10-day feeding period.
At the end of each 10-day feeding period, participants will spend two nights in a research ward (Clinical Research Center) to undergo testing.
Overweight and ObesityDietSugarCardiovascularLipid
You can join if…
Open to people ages 20–65
overweight or obese men and women
ages 20-65 years
You CAN'T join if...
pregnancy or lactation within the past six months
type 1 or 2 diabetes mellitus]
AST and ALT above upper limit of normal (ULN)
fasting triglyceride or total cholesterol levels >ULN
Hgb below the lower of limit of normal
positive HIV antibody test or hepatitis serologies
use of any antidiabetic medications or lipid-lowering drugs
history of surgery for obesity
change in body weight >5% within preceding 6 months (self report)
claustrophobia, presence of metal implants
weight over 350 lbs
University of California, San Franciso, San Francisco General Hospitalaccepting new patients San Francisco, California, 94110, United States