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for females ages 25 years to 40 years
Healthy Volunteers
healthy people welcome
at Sacramento, California
study started
estimated completion:



The main objectives of this study are to test the hypotheses that: 1) consumption of beverages sweetened with sucrose will increase risk factors for cardiovascular disease to a greater extent than a naturally-sweetened fruit juice such as orange juice, and 2) chronic psychological stress may augment the adverse metabolic effects of sugar intake. The study intervention consists of 2-week's consumption of 25% of energy as sugar provided either as a sucrose-sweetened beverage or naturally-sweetened orange juice.

Official Title

Synergistic Effects of Stress and Sugar Feeding on Metabolism


Metabolic Syndrome Insulin Resistance Dyslipidemia sugar sucrose fruit juice orange juice metabolism immune cell aging lipids


You can join if…

Open to females ages 25 years to 40 years

  • Body mass index between 28-35
  • Self report of stable body weight during the past six months
  • High stress participants: Perceived Stress Scores (PSS) ≥ 24, and the presence of a predefined chronically stressful event as assessed by the Telephone screening questions. (IDS scores are not an inclusion criteria in this group, merely a rule-out for the low stress participants).
  • Low stress participants: PSS scores ≤ 8, Inventory for Depressive Symptom (IDS)scores ≤ 14, and the absence of any predefined chronically stressful events as assessed by the telephone screening questions.

You CAN'T join if...

  • glucose intolerance
  • Evidence of liver disorder
  • Evidence of kidney disorder
  • Evidence of thyroid disorder
  • Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over 90mmHg
  • Triglycerides> 200mg/dl
  • LDL-C> 130mg/dl
  • Hemoglobin < 8.5 g/dl
  • pregnant or lactating women
  • Current, prior (within 12 months), or anticipated use of any hypolipidemic or anti-diabetic agents
  • Use of Selective Serotonin Reuptake Inhibitors and anti-hypertensive medications
  • Any other condition that, in the opinion of the investigators, would put subject at risk
  • Strenuous exerciser
  • surgery for weight loss
  • Diet exclusions: food allergies, special dietary restrictions, habitual ingest of>2 alcoholic beverages/day


  • Clinical Research Center accepting new patients
    Sacramento, California, 95655, USA


accepting new patients
Start Date
Completion Date
University of California, Davis
Study Type
Last Updated
December 2016
I'm interested in this study!