Skip to main content
Eligibility
for people ages 18 years and up
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:

Description

Summary

Background: - Neurocysticercosis (NCC) is caused by tapeworms that infect people. NCC can lead to serious brain problems such as seizures, sevre headaches and difficulties with movements or sensation in the limbs. Researchers want to learn more about the different ways in which people in the United States present with this disease and how they respond to standard and newer treatments. Objective: - To learn about the different forms of NCC that occurs throughout North America and how patients with these forms respond to treatment. Eligibility: - Adults age 18 or older with NCC. Design: - Participants will be screened with: - Medical history and physical exam. - A computed tomography (CT) brain scan The participant will lie still on a table that slides into a large donut-shaped scanner. - Blood drawn through an arm vein for analysis - A magnetic resonance imaging (MRI) scan of the brain and spine. They will lay flat in a long metal cylinder as the machine makes images of the body. During the scan, participants will receive a contrast agent through an IV that allows high resolution imaging of the brain and spine - Participants will visit the clinic at 0, 1, 2, 3, 6, 12, and 24 months (7 times), and depending on the need for monitoring, more times. Participants will receive a schedule that will explain the procedures done at each visit. - At these visits, participants may: - Repeat the screening procedures. - Be asked about their NCC symptoms and their physical and mental health. - Have a urine test. - Take a test of their ability to concentrate, their memory and spatial recognition. - Have a lumbar puncture, if indicated by the state and severity of infection. A needle will be inserted through the skin and into the space between the bones in the back. Cerebrospinal fluid will be removed.

Official Title

NACC 002: A Multicenter Prospective Natural History Study of Patients Presenting With Neurocysticercosis in North America

Details

Neurocysticercosis (NCC) is the most common helminthic CNS infection and the main cause of adult-onset seizures in low-to-middle income countries. Studies have documented significant endemicity in Latin America, Eastern Europe, sub-Saharan Africa, India and other parts of the world. The prevalence of NCC in North America is rising as a result of increased migration of people with the disease and, occasionally, immigration of individuals with asymptomatic tapeworms. Despite the gains in knowledge and understanding of the epidemiology, pathophysiology, diagnosis, and treatment, clinical care continues to be hampered by unanswered fundamental questions related to optimal diagnosis, staging, treatment, and follow-up of patients with NCC.

This multi-center, natural history study seeks to characterize: the frequency of the various forms of NCC in North American populations; the spectrum of treatment and management strategies across the North American Cysticercosis Consortium; and the response to therapy by evaluating a number of endpoints related to disease evolution and treatment, such as burden of disease, cognitive changes, radiographic changes, and treatment complications. This study will inform future research studies needed to eventually establish standardized management protocols for each form of this complex infection.

Subjects will have visits at screening, baseline, 1, 2 (optional), 3, 6, 12, and 24 months. Evaluations will include assessment of clinical status, antigen assays, radiographic imaging, functional assessments, immunologic evaluations, cognitive assessments, and quality of life measures. Additional clinically indicated visits may be scheduled as needed. This study does not provide any interventional therapies but will collect data on the course of treatment. Diagnostic examinations, consultations and medical treatment will be determined by the study clinician. Any samples removed for medical indications related to NCC may be evaluated for research purposes.

Keywords

Neurocysticercosis Seizures Cestode Hydrocephalus Taenia Solium Helminth

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Adults greater than or equal to18 years of age.
  2. Subject, or Subject s Legally Authorized Representative (LAR)/ Durable Power of Attorney (DPA), is able to provide informed consent and agree to allow samples to be stored for future research.
  3. Previously or currently diagnosed with definitive or probable NCC by a practitioner at NACC in accordance with the Del Brutto criteria modified for use in a North American populations.

    For the purpose of this study, definitive and probable diagnostic certainty based on presence of criteria below.

    Definitive diagnosis

  4. Presence of 1 absolute criterion
  5. Presence of 2 major + 1 minor + 1 epidemiological criterion

    Probable diagnosis Presence of 1 major + 2 minor criterion

  6. Presence of 1 major + 1 minor + 1 epidemiological criterion
  7. Presence of characteristic calcification(s)

    Del Brutto Diagnostic criteria

  8. Absolute criteria
  9. Biopsy of a brain or spinal cord lesion
  10. Cystic lesion with scolex on CT or MRI
  11. Fundoscopic examination (subretinal parasites)
  12. Major criteria
  13. Highly suggestive lesions on neuroimaging
  14. Positive serum enzyme-linked immunotransfer blot (EITB) assay
  15. Resolution of intracranial cysts after therapy
  16. Spontaneous resolution of small single enhancing lesions
  17. Minor criteria
  18. Compatible lesions on neuroimaging
  19. Clinical manifestations suggestive for NCC (eg, headaches, seizures,neurological symptoms)
  20. Positive CSF ELISA for specific Ag/Ab
  21. Cysts outside CNS
  22. Epidemiological criteria
  23. Evidence of household contact with T. solium
  24. Individuals coming from/living in endemic areas
  25. History of frequent travel to endemic areas
  26. Single or multiple characteristic calcifications in subjects who meet epidemiologic criteria (4) without another identifiable etiology will be considered NCC in the case of calcified granulomas

You CAN'T join if...

  1. Subjects that in the opinion of the investigator have contraindications for participation in the study will be excluded, such as patients with current substance abuse or patients currently undergoing cancer chemotherapy.

    Justification for Exclusion or Inclusion of Special Populations

    Children

    Children are eligible to participate in this clinical trial but will not be enrolled at the NIH because the NIH investigators do not see nor specialize in pediatric populations.In addition, NCC in the U.S. generally afflicts travelers and immigrants and is therefore exceedingly rare in pediatric populations in the U.S.

    Adults Unable To Provide Consent-

    Patients will be offered standard of care treatment delivered irrespective of cognitive status, including lumbar punctures that are used clinical management decisions as determined by the site PI. Exclusion of patients unable to provide consent because of cognitive impairment would limit the study population significantly, and potentially compromise the generalizability of results from this observational study. In cases where cognitive function precludes informed consent we will seek consent from the designated legal guardian.

Locations

  • University of Washington accepting new patients
    Seattle, Washington, 98195, United States
  • UT Southwestern Medical Center accepting new patients
    Dallas, Texas, 75390, United States
  • National Institutes of Health Clinical Center, 9000 Rockville Pike accepting new patients
    Bethesda, Maryland, 20892, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Links
NIH Clinical Center Detailed Web Page
ID
NCT02233855
Study Type
Observational
Last Updated
July 1, 2016
I'm interested in this study!