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Summary

at San Francisco, California
study started
estimated completion:

Description

Summary

This is a non-interventional cohort study to assess a novel assay to detect excessive or insufficient immunosuppression from the drug tacrolimus in lung transplant recipients. The assay measures mean residual expression (MRE) of genes downstream of NFAT, a transcription factor regulated by tacrolimus. The investigators will assess whether MRE levels identify subjects at risk for rejection (insufficient immunosuppression) or infection (excessive immunosuppression).

Keywords

Transplantation, Lung Tacrolimus

Eligibility

You can join if…

The study will include lung allograft recipients within 2 months of transplantation at UCSF.

You CAN'T join if...

Subjects will be excluded who are (a) unable to provide consent of (b) if treating clinicians do not anticipate subject will start on tacrolimus. Recruitment and enrollment in this study are targeted equally between women and minorities and the study will not exclude and gender or racial/ethnic group. This study does not involve vulnerable populations.

Location

  • University of California
    San Francisco, California, 94143, United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT02278952
Lead Scientist
Greenland John
Study Type
Observational
Last Updated
October 26, 2016