To protect kidney function during the transplantation process by comparing mild hypothermia in the deceased organ donor before organs are recovered and pulsatile perfusion of the kidney while being transported to the recipient.
Mild Hypothermia Versus Pulsatile Perfusion in Deceased Donors and Kidney Graft Function
The number of kidneys available for transplantation in the U.S. (~15,000/yr) does not meet demand (~80,000/yr). This discrepancy will likely worsen given the increasing U.S. prevalence of chronic kidney disease and is compounded by sizable organ attrition once organs have entered the donation process (25-30% attrition in Region 5). Furthermore, worsening renal function in donation after neurologic determination of death (DNDD) organ donors (an increasingly important source of allografts) is one of the strongest predictors of delayed graft function (DGF) and slow graft function (SGF) in the recipient. Both DGF and SGF are associated with decreased long-term organ survival and are of major concern to the transplant community.
The investigators will accomplish this goal by extending an existing research infrastructure across several donor service areas. Infrastructure and logistics will be based on the investigators' successful completion of NCT01680744.
Delayed Graft Function
You can join if…
Open to people ages 18 years and up
> 18 years of age, deceased organ donor
You CAN'T join if...
< 18 years of age, not a deceased organ donor
U C San Francisco San Francisco, California, 94143, United States