Skip to main content

Summary

for males ages 18–50 (full criteria)
healthy people welcome
at San Francisco, California and other locations
study started
Josh D Woolley

Description

Summary

In this study, investigators will examine the behavioral effects and neurophysiological mechanisms of the pro-social neuropeptide oxytocin in patients with recent-onset schizophrenia. Such research is a necessary first step towards identifying whether intranasal oxytocin administration can serve as an adjunct treatment for social impairments in schizophrenia. Aim 1: To examine the effects of exogenous oxytocin on patterns of neural activation as measured by fMRI during a well-characterized affect-labeling task in patients with recent-onset schizophrenia and healthy comparison subjects. Hypothesis A: Patients will exhibit amygdalar hyperactivity and PNS hypo-activity when passively viewing faces, which will be normalized by administration of oxytocin. Hypothesis B: Patients will exhibit hypo-activity of the vPFC when affectively labeling faces and this hypo-activity will be normalized by oxytocin administration.

Official Title

Mechanisms and Effects of Oxytocin on Social Cognition in Schizophrenia - fMRI

Keywords

Schizophrenia Oxytocin Social Cognition Functional Magnetic Resonance Imaging (fMRI) Syntocinon

Eligibility

You can join if…

Open to males ages 18–50

for Patients:

  • Male
  • SCID-IV confirmed diagnosis of schizophrenia or schizoaffective disorder
  • Clinically stable
  • No changes to medications for the past week

Inclusion Criteria for Healthy Controls:

  • Male
  • SCID-IV confirmed no diagnosis of a current Axis I disorder within the last year

You CAN'T join if...

for Patients and Healthy Controls:

  • Meeting criteria for current substance abuse or dependence or illicit drug use within the last month (nicotine use is acceptable) as determined by a Urine Toxicology Drug Screening
  • Any illness that affects the nasal passages and impairs the delivery of a nasal spray
  • Presence of any neurological or significant medical disorder, including medical illnesses that could interfere with physiological recording such as cardiac arrhythmias
  • A pacemaker, extensive dental work, or any magnetic metal implants and upper body tattoos
  • Pregnancy
  • Claustrophpbia
  • Hearing difficulties
  • A history of seizures
  • Failure to receive a passing score on the reading test

Additional Exclusion Criteria for Patients and Healthy Controls:

  • Taking any psychotropic medication or any medication that affects the autonomic or cardiovascular systems.
  • Schizophrenia or other psychotic disorder in a first degree relative
  • Failure to receive a passing score on the MOCA

Locations

Details

Status
accepting new patients
Start Date
Sponsor
University of California, San Francisco
ID
NCT02566356
Phase
Phase 1
Lead Scientist
Josh D Woolley
Study Type
Interventional
Last Updated
September 2016
I’m interested in this study!