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Eligibility
for males ages 18–40
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
Principal Investigator
Josh D Woolley

Description

Summary

The specific aim of this proposal is to investigate the neurophysiological mechanisms of oxytocin's (OT) prosocial effects in patients with schizophrenia and healthy subjects using magnetoencephalography. Hypothesis A: When OT is administered to patients with schizophrenia, fear-related amygdala hyperreactivity and fusiform gyrus (FG) and anterior cingulate cortex (ACC) hypoactivity will be normalized. Hypothesis B: When OT is administered to patients with schizophrenia, the decreased functional connectivity (FC) between the amygdala, FG, and ACC will be normalized. By elucidating the neurophysiological mechanisms of OT administration on emotional face processing, investigators will bee able to: 1. understand the pathophysiology of the functionally debilitating social cognitive deficits of schizophrenia, 2. test the efficacy of OT in normalizing the neural abnormalities underlying these social deficits, and 3. develop and optimize novel treatments for these currently untreatable deficits.

Official Title

Effects of Oxytocin on Neural Activation Patterns During Social Cognitive Tasks in Patients With Schizophrenia

Keywords

Schizophrenia Oxytocin Magnetoencephalography (MEG) Social Cognition Syntocinon

Eligibility

You can join if…

Open to males ages 18–40

for Patients:

  • 18-40 years of age
  • Male
  • Must comprehend English
  • Meet DSM-IV criteria for schizophrenia, schizophreniform or schizoaffective disorder
  • None or only minor changes to medications in the past week
  • Able to use nasal spray
  • Must be capable of providing informed consent
  • Clinically stable

Inclusion Criteria for Healthy Controls:

  • 18-40 years of age
  • Male
  • Must comprehend English
  • No diagnosis of mental disorder according to DSM-IV TR
  • Able to use nasal spray
  • Must be capable of providing informed consent
  • Clinically stable

You CAN'T join if...

  • Female
  • Active substance abuse or dependence as determined by a Urine Toxicology Drug Screening
  • DSM-IV diagnosis of any disorder other than schizophrenia
  • Medical conditions (atrophic rhinitis, recurrent nose bleeds and cranial surgical procedures (hypophysectomy), congestion or sinus problems that could interfere with the study as per the opinion of the investigator
  • Hearing deficits
  • A pacemaker, extensive dental work, or any magnetic metal implants
  • Any history of severe brain trauma

Location

Details

Status
in progress, not accepting new patients
Start Date
Sponsor
University of California, San Francisco
ID
NCT02568709
Phase
Phase 1
Lead Scientist
Josh D Woolley
Study Type
Interventional
Last Updated
July 18, 2016