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Summary

Eligibility
for people ages 55 years and up
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

The purpose of this study is to determine whether metformin, an FDA-approved drug for the treatment of type II diabetes, is a safe and effective treatment to decrease the progression of geographic atrophy in non-diabetic patients with Age-related Macular Degeneration (AMD).

Official Title

METforMIN: Metformin Administration for the Minimization of Geographic Atrophy Progression in Patients With Age-related Macular Degeneration

Details

This is a phase II, single-blind, randomized, evaluation of the safety and efficacy of metformin use to decrease geographic atrophy (GA) progression in non-diabetic patients with dry Age-related Macular Degeneration (AMD). Approximately 100 study subjects throughout four separate study sites will be randomized in a 1:1 ratio to the treatment group and the observation group. The treatment group will be assigned to the study intervention (oral Metformin) for 18 months while the observation group will receive no intervention for 18 months, instead continuing with standard of care ophthalmic exams and close monitoring of their disease. Throughout the 18 month study period, the progression of subjects' GA will be measured via ocular imaging taken at standard of care follow-up examinations, including fundus autofluorescence imaging, optical coherence tomography (OCT), and fundus photography.

Keywords

Age-Related Macular Degeneration Macular Degeneration, Age-Related Dry Macular Degeneration Geographic Atrophy Metformin

Eligibility

You can join if…

Open to people ages 55 years and up

  • Subject must be>/= 55 years of age
  • Subject must have evidence of advanced dry AMD, defined by the characteristic presence of drusen and/or pigmentary changes as well as geographic atrophy
  • Subject must have clear ocular media and adequate pupillary dilation
  • Subject must be able to swallow capsules
  • Study eye must have best corrected visual acuity (BCVA) of 20/20-20/400
  • Subject must be willing and able to pay for monthly prescription of Metformin HCl for 18 months in the event that their insurance carrier will not cover the cost of the drug

You CAN'T join if...

  • Subjects with insufficient baseline size of geographic atrophy, less than 1.25 mm2(0.5 Macular Photocoagulation Study Disc Areas). GA is defined as one or more well-defined and often circular patches of partial or complete depigmentation of the RPE, typically with exposure of underlying choroidal blood vessels. Even if much of the RPE appears to be preserved and large choroidal vessels are not visible, a round patch of RPE partial depigmentation may be classified as early GA. The GA in the study eye must be able to be photographed in its entirety, and it must not be contiguous with any areas of peripapillary atrophy, which can complicate area measurements.
  • Subjects who are already taking metformin for another purpose
  • Subjects with type 1 or 2 diabetes
  • Subjects with compromised kidney function:
  • Serum creatinine ≥1.5 mg/dL for males and ≥1.4 mg/dL for females
  • Subjects with moderate to severe heart failure (Class III or IV, New York Heart Association Functional Classifications)
  • Subjects with Child's class C cirrhosis
  • Evidence of retinal atrophy due to causes other than atrophic AMD.
  • Subjects who have had anti-VEGF injections or active choroidal neovascularization in the study eye during the last 12 months
  • Current evidence or history of ocular disorders in the study eye that in the opinion of the investigator confounds study outcome measures, including (but not limited to):

    1. Non-proliferative diabetic retinopathy involving 10 or more hemorrhages or microaneurysms, or active proliferative diabetic retinopathy
    2. Branch or central retinal vein or artery occlusion
    3. Macular hole
    4. Pathologic myopia
    5. Uveitis
    6. Pseudovitelliform maculopathy
    7. Intraoperative surgery within the last 90 days prior to study eye enrollment

Locations

  • University of California, Davis accepting new patients
    Davis, California, 95616, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT02684578
Phase
Phase 2
Lead Scientist
Jay Stewart
Study Type
Interventional
Last Updated
March 1, 2017
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