In this pre-post observational study, the investigators will enroll and follow a cohort of about 50 adults undergoing sleeve gastrectomy surgery for weight loss. Pre-operatively and at 6 and 12 months post-operatively, the investigators will use state-of-the-art metabolic and imaging techniques to evaluate calcium metabolism and skeletal health. Specific outcomes include intestinal calcium absorption capacity, bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), and bone structure assessed by QCT and high-resolution peripheral QCT (HR-pQCT).
Calcium Metabolism DisordersMorbid Obesitysleeve gastrectomy, bariatric surgery
You can join if…
Open to people ages 25 years to 70 years
Women and men 25 to 70 years old scheduled to undergo sleeve gastrectomy
Please note that the investigators are unable to provide sleeve gastrectomy; rather,potential participants must already be planning the procedure with their surgeons.
You CAN'T join if...
Perimenopausal women, defined as last menses>3 months but < 5 years ago
Known intestinal malabsorption (e.g., celiac disease, short gut syndrome, prior intestinal surgery)
Prior bariatric surgery
Use of medications known to impact bone and mineral metabolism, including use of a bisphosphonate or teriparatide in the last year or for>12 months ever; current calcitonin; prednisone>5 mg daily or the equivalent glucocorticoid for>10 days in the last 3 months; a current thiazolidinedione (TZD); an aromatase inhibitor;androgen deprivation therapy; an antiepileptic agent known to alter hepatic vitamin D clearance; or thyroid hormone replacement with current thyroid stimulating hormone <0.1 milli-international units per liter
Disease known to affect bone (e.g., primary hyperparathyroidism, Pagets disease,clinically significant liver disease)
Illicit drug use or alcohol use>3 drinks/day
Serum calcium>10.2 mg/dL or calculated creatinine clearance < 30 mL/min
Weight>350 pounds (the maximum weight limit of the QCT scanner) at the time of the pre-operative QCT scan
UCSFaccepting new patients San Francisco, California, 94143, USA