Skip to main content

Summary

Eligibility
for people ages 18–70
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls which will compare asthmatic smooth muscle cells to non-asthmatic smooth muscle cells collected from bronchial biopsies.

Official Title

The Regulation of RhoA Activation in Airway Smooth Muscle

Details

In an asthma exacerbation, contraction of airway smooth muscle leads to airway narrowing. Airway smooth muscle contractility is increased by the activation of the intracellular protein Rho. The current research seeks to understand the biology of regulation of Rho activation in airway smooth muscle in order to further understand the pathophysiology of asthma and to reveal potential targets for the development of molecular therapies.

Keywords

Asthma

Eligibility

You can join if…

Open to people ages 18–70

(Healthy participants):

  1. Male and female subjects between the ages of 18 and 70 years
  2. Ability to provide written informed consent and ability to comply with the requirements of the study
  3. No hyperreactivity to methacholine (PC20 FEV1 Methacholine>16 mg/mL)
  4. No history of allergic rhinitis/seasonal allergies

Inclusion Criteria (Asthmatic participants):

  1. Male and female subjects between the ages of 18 and 70 years
  2. Ability to provide written informed consent and ability to comply with the requirements of the study
  3. History of asthma
  4. No use of oral or inhaled corticosteroids for the treatment of asthma during the past 6 weeks
  5. Hyperreactivity to methacholine (PC20 FEV1 Methacholine < 8 mg/ml)

You CAN'T join if...

The same exclusion criteria will apply to both Sub-studies.

  1. Current smokers, defined by (a)>5 cigarettes smoked in past 12 months, and (b) ≤ 8 weeks since last time smoking; or former smokers who have a total smoking history ≥10 pack-years
  2. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
  3. Subjects with a history of lung disease other than asthma
  4. Subjects with a history of a medical disease, which in the opinion of the Investigator may put the subject at extra risk from study-related procedures or because the disease may influence the results of the study
  5. Current participation in an investigational drug trial

Location

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT02791542
Lead Scientist
Nirav Bhakta
Study Type
Observational
Last Updated
March 1, 2017
I’m interested in this study!