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for people ages up to 21 years
at San Francisco, California and other locations
study started
estimated completion:



Noninvasive monitoring of liver fibrosis is an unmet need within the clinical management of pediatric chronic liver disease. While liver biopsy is often used in the initial diagnostic evaluation, subsequent biopsies are rarely performed because of inherent invasiveness and risks. This study will evaluate the role of non-invasive FibroScan™ technology to detect and quantify liver fibrosis.

Official Title

Childhood Liver Disease Research Network (ChiLDReN): FibroScan™ in Pediatric Cholestatic Liver Disease Study Protocol


Noninvasive monitoring of liver fibrosis is an unmet and critical need within the clinical management of children with chronic liver disease. While liver biopsy is often used in the initial diagnostic evaluation of children with liver disease, subsequent surveillance liver biopsy is rarely performed in children because of its inherent invasiveness and risks. Therefore, our understanding of the natural history of fibrosis progression in children is limited. The patchy nature of fibrosis in many important pediatric liver diseases [e.g. biliary atresia (BA) and cystic fibrosis liver disease (CFLD)] limits the utility of sequential liver biopsy even if it were to be employed in clinical practice in pediatrics. Thus, non-invasive means of assessing liver fibrosis throughout the liver would be highly desirable and clinically useful in pediatric hepatology. ChiLDReN is poised and uniquely qualified to conduct a comprehensive longitudinal assessment of the utility of FibroScan™-specific elastography, liver stiffness measurement (LSM) as a measure of hepatic fibrosis in children with serious chronic cholestatic liver disease.


Biliary Atresia Alagille Syndrome Alpha1 Anti-Trypsin Deficiency Portal Hypertension Liver Fibrosis Cholestasis transient elastography pediatric liver disease Liver Extracts Alpha 1-Antitrypsin


You can join if…

Open to people ages up to 21 years

  • Age less than 21 years at the time of enrollment
  • Participants enrolled in a ChiLDReN based prospective observational cohort study(PROBE, BASIC, or LOGIC)
  • Willingness and ability to participate in the study for up to 24 months
  • One of the following three diagnoses
  • Biliary atresia per ChiLDReN criteria or,
  • Alpha-1 antitrypsin deficiency (PiZZ or SZ) or,
  • Alagille Syndrome per ChiLDReN criteria

You CAN'T join if...

  • BA with known situs inversus or polysplenia/asplenia
  • Presence of clinically significant ascites detected on physical examination
  • Open wound near expected FibroScan probe application site
  • Use of implantable active medical device such as a pacemaker or defibrillator
  • Known pregnancy
  • Prior liver transplant
  • Unable or unwilling to give informed consent or assent


  • Children's Hospital Colorado
    Aurora, Colorado, 80045, USA
  • Children's Healthcare of Atlanta
    Atlanta, Georgia, 30322, USA
  • Ann & Robert H. Lurie Children's Hospital of Chicago
    Chicago, Illinois, 60611, USA
  • Riley Hospital for Children
    Indianapolis, Indiana, 46202, USA
  • Cincinnati Children's Memorial Hospital
    Cincinnati, Ohio, 60190, USA
  • Texas Children's Hospital
    Houston, Texas, 77030, USA
  • Seattle Children's Hospital
    Seattle, Washington, 98105, USA
  • Hospital for Sick Children
    Toronto, Ontario, M5G 1X8, Canada


accepting new patients by invitation only
Start Date
Completion Date
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ChiLDReN Study Network Website
Study Type
Last Updated
February 2017