This study involves the prospective collection of endometrial biopsy tissue, serum, plasma, whole blood for DNA extraction, and urine from women who will be diagnosed as having (or not having) endometriosis at the time of scheduled surgery. The investigators plan to enroll approximately 500 women to validate and optimize the use of genomic classifiers alone or in combination with serum markers (such as cytokines) as a non-surgical marker of disease.
You can join if…
Open to females ages 18–44
• Currently pregnant
Current or past diagnosis of any malignancy (with the exception of non-melanoma skin cancer)
Known to be HIV-positive
Unable to give informed consent
Unwillingness to have samples banked in Repository for future use
Clinical evidence of active cervical infection
Lupron (or other GRH agonist) therapy within the last 2 months (or Depo-Lupron within the last 4 months)
Current use of estrogen or progestin (oral, transdermal, intrauterine or ring).
o Current use is defined as use in the index menstrual cycle (since the onset of the last menstrual period).
Use of depo estrogen or progestin in last 3 months
Current use of aromatase inhibitor
You CAN'T join if...
Women aged 18-44 scheduled to undergo gynecologic surgery (laparoscopy/laparotomy).
Indication for surgery can include: infertility, endometriosis, tubal ligation, lysis of adhesions, pelvic pain, hysterectomy (for benign condition), myomectomy,salpingo-oophorectomy, cystectomy, or diagnostic laparoscopy.
University of California San Francisconot yet accepting patients San Francisco, California, 94115, United States
University of Oklahomanot yet accepting patients Oklahoma City, Oklahoma, 73104, United States
Wayne State Universitynot yet accepting patients Southfield, Michigan, 48034, United States
Augusta Universitynot yet accepting patients Augusta, Georgia, 30912, United States
University of North Carolinanot yet accepting patients Chapel Hill, North Carolina, 27599, United States
Pennsylvania State Universityaccepting new patients Hershey, Pennsylvania, 17033, United States
University of Pennsylvanianot yet accepting patients Philadelphia, Pennsylvania, 19104, United States