The purpose of this study is to determine if high-dose PUFA supplementation in patients undergoing EVAR for infra-renal AAA reduces the peri-operative inflammation.
THE OMEGA-EVAR TRIAL: USE OF FISH OIL TO REDUCE INFLAMMATION DURING ENDOVASCULAR ABDOMINAL AORTIC REPAIR
In this 2:1 double-blind, randomized, placebo controlled trial, subjects will be given an active drug of n-3 polyunsaturated fatty acids (PUFAs) or a placebo soybean oil for about two weeks prior to an endovascular abdominal aortic repair (EVAR) and subsequently six months after the procedure.
An EVAR is known to produce a systemic inflammatory response with an increased risk of prolonged hospitalization and complicated post-operative recovery with cardiac events, renal and pulmonary dysfunction, and multiple organ failure. The study proposed here has the potential to provide valuable insight on the role of nutritional intervention to improve outcomes related to surgical revascularization.
PADAbdominal Aortic Aneurysm
You can join if…
Open to people ages 40–90
Undergoing EVAR for infra-renal AAA and/or iliac artery aneurysm
You CAN'T join if...
Age < 40 or> 90 years
On dual antiplatelet therapy or anticoagulation
Evidence of active infection
Diagnosed hypercoagulable state
Non-atherosclerotic/aneurysmal disease as indication for procedure
Chronic liver disease or myopathy
End-stage renal disease (CKD 5)
Poorly controlled diabetes (HbA1C> 8%)
Recent other major surgery or illness within 6 weeks
Use of immunosuppressive medication or extant chronic inflammatory disorders
History of organ transplantation
Pregnancy or plans to become pregnant
Condition in which patient life expectancy is less than one year
Known allergy to fish or fish products
Presence of symptomatic or ruptured AAA
San Francisco Veteran Affairs Medical Centeraccepting new patients San Francisco, California, 94121, United States