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Resistance Bacterial clinical trials at UCSF

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  • Azithromycin for Child Survival in Niger: Implementation and Research (AVENIR)

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    The trial, Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) (NCT02047981) demonstrated that biannual distribution of azithromycin to children 1-59 months old reduces child mortality. Targeting treatment to children 1-11 months old could reduce selection for resistance by limiting antibiotic distributions while maximizing the mortality benefit by targeting treatment to children at the highest mortality risk. Such a targeted intervention remains untested, however. The investigator's objective in this study is to determine the optimal age group to treat with biannual oral azithromycin distribution to reduce child mortality.

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