Summary

for people ages 18-40 (full criteria)
healthy people welcome
at San Francisco, California
study started
estimated completion:
Kathleen M Giacomini

Description

Summary

Collect DNA from well-characterized healthy volunteers.

Details

DNA and plasma will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations.

Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.

Keywords

Focus Groups Healthy Cohort African American Cuacasian Hispanic Asian

Eligibility

You can join if…

Open to people ages 18-40

  • Healthy adult subjects of both genders and specified ethnic groups
  • Subjects must be between 18-40 years of age

You CAN'T join if...

  • Smokers
  • Drink > 2 alcoholic beverages/day
  • Take any chronic medication

Location

  • San Francisco General Hopsital CTSI CRC
    San Francisco California 94143 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT00187668
Lead Scientist
Kathleen M Giacomini
Study Type
Observational
Last Updated