at Oakland, California and other locations
study started



This laboratory study is collecting and storing samples of tissue and blood from young patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help the study of cancer in the future.

Official Title

Hodgkin Disease (HD) Banking Study



  1. Establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma.

II. Provide specimens from diagnosis, early response evaluation, completion of chemotherapy and radiotherapy, long-term follow up, and relapse to study prognostic factors for early response, relapse, long-term outcomes, and identification of new biological targets for therapy.

OUTLINE: This is a multicenter study.

Patients enrolled on Hodgkin's lymphoma (HL) therapeutic clinical trials undergo collection of tumor tissue samples at baseline and at relapse or disease progression. Serum and anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after diagnosis, and at relapse or disease progression.

Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral blood samples at relapse or disease progression.

Patients enrolled more than 1 year after completion of treatment undergo collection of tumor specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation.


Refractory Childhood Hodgkin Lymphoma Stage I Childhood Hodgkin Lymphoma Stage II Childhood Hodgkin Lymphoma Stage III Childhood Hodgkin Lymphoma Stage IV Childhood Hodgkin Lymphoma Lymphoma Hodgkin Disease Cytology Specimen Collection Procedure Ancillary-correlative (specimen collection and baking)


Inclusion Criteria:

  • Histologically confirmed Hodgkin's lymphoma (HL) meeting 1 of the following criteria:
  • Newly diagnosed, untreated HL (for patients under 22 years of age)
  • Past or present diagnosis of HL and past or present enrollment on a Children's Oncology Group (COG) or legacy HL clinical trial (for patients of any age)


  • Children's Hospital and Research Center at Oakland
    Oakland California 94609-1809 United States
  • UCSF Medical Center-Mission Bay
    San Francisco California 94158 United States
  • Kaiser Permanente-Oakland
    Oakland California 94611 United States
  • Children's Hospital Central California
    Madera California 93636-8762 United States


in progress, not accepting new patients
Start Date
Children's Oncology Group
Study Type
Last Updated
May 2017