Summary

for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started

Description

Summary

This randomized phase III trial studies giving everolimus together with bevacizumab to see how well it works compared to everolimus alone in treating patients with advanced kidney cancer that progressed after first-line therapy. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can interfere with tumor growth by blocking the ability of tumor cells to grow and spread. Everolimus and bevacizumab may also stop the growth of kidney cancer by blocking blood flow to the tumor. It is not yet known whether giving everolimus together with bevacizumab is better than everolimus alone in treating patients with advanced kidney cancer that has progressed after first-line therapy.

Official Title

Randomized Phase III Trial Comparing Everolimus Versus Everolimus Plus Bevacizumab for Advanced Renal Cell Carcinoma Progressing After Treatment With Tyrosine Kinase Inhibitors

Details

PRIMARY OBJECTIVES:

  1. To compare the overall survival of patients receiving bevacizumab plus everolimus and everolimus alone among patients with advanced renal cell carcinoma progressing after first line vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitor (TKI) treatment.

SECONDARY OBJECTIVES:

  1. To compare the progression-free survival and proportion who experience an objective response (defined as complete clinical response [cCR] + partial response [PR]) in patients with advanced renal cell carcinoma receiving bevacizumab plus everolimus and everolimus alone.

II. To compare grade 3 or higher toxicity in patients receiving each treatment regimen.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive everolimus orally (PO) once daily (QD) on days 1-28.

ARM II: Patients receive everolimus PO QD on days 1-28 and bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 8 weeks until disease progression and then every 6 months for up to 5.5 years.

Keywords

Clear Cell Renal Cell Carcinoma Recurrent Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v7 Stage IV Renal Cell Cancer AJCC v7 Carcinoma Carcinoma, Renal Cell Bevacizumab Everolimus Sirolimus Endothelial Growth Factors Antibodies Immunoglobulins Antibodies, Monoclonal Immunoglobulin G Laboratory Biomarker Analysis Pharmacological Study

Eligibility

For people ages 18 years and up

Inclusion Criteria:

  • Renal cell carcinoma with some component of clear cell histology
  • Metastatic or unresectable disease
  • Must have been treated with at least 1 prior VEGFR tyrosine kinase inhibitor treatment and have progressed or have been intolerant to treatment
  • No prior systemic therapy with a vascular endothelial growth factor (VEGF) binding agent (e.g., bevacizumab)
  • No prior systemic therapy with any mechanistic target of rapamycin (mTOR) inhibitor(e.g., sirolimus, temsirolimus, everolimus)
  • Prior cytokine therapy is allowed
  • Any systemic therapy must be completed at least 4 weeks prior to registration
  • >= 2 weeks since any prior radiation (including palliative)
  • Patients must not have had a major surgical procedure, open biopsy, or significant traumatic injury within 4 weeks prior to study registration, and must have fully recovered from any such procedure
  • The following are not considered to be major procedures: thoracentesis,paracentesis, port placement, laparoscopy, thoracoscopy, bronchoscopy, endoscopic ultrasonographic procedures, mediastinoscopy, skin biopsies, incisional biopsies and routine dental procedures
  • Patients must have measurable disease by RECIST criteria; lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as >=2 cm with conventional techniques or as >= 1 cm with spiral computed tomography (CT)scan
  • No active brain metastases: patients with treated, stable brain metastases for at least three months are eligible as long as they meet the following criteria:
  • Treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 3 months, as ascertained by clinical examination and brain imaging(magnetic resonance imaging [MRI] or CT) (stable dose of anticonvulsants are allowed); treatment for brain metastases may include whole brain radiotherapy(WBRT), radiosurgery (RS; Gamma Knife, linear accelerator [LINAC], or equivalent)or a combination as deemed appropriate by the treating physician; patients with central nervous system (CNS) metastases treated by neurosurgical resection or brain biopsy performed within 3 months prior to day 1 are not eligible
  • Baseline brain imaging (MRI/CT) is required
  • No serious non-healing wound, ulcer, or bone fracture
  • No arterial thrombotic events within 6 months of registration:
  • Including transient ischemic attack (TIA), cerebrovascular accident (CVA),peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the past 6 months, or myocardial infarction (MI);patients with clinically significant peripheral artery disease (i.e.,claudication on less than one block), significant vascular disease (i.e., aortic aneurysm, history of aortic dissection), or any other arterial thrombotic event are ineligible
  • Patients who have experienced a deep venous thrombosis or pulmonary embolus within the past 6 months must be on stable therapeutic anticoagulation to be enrolled to this study
  • Patients receiving anti-platelet agents and prophylactic anticoagulation are eligible
  • No inadequately controlled hypertension: (defined as a blood pressure of >= 160 mmHg systolic and/or >= 90 mmHg diastolic on medication), or any prior history of hypertensive crisis or hypertensive encephalopathy
  • No known severe impairment of lung function, defined as >= grade 2 dyspnea or cough,or either:
  • Requirement of supplemental oxygen, or
  • In cases where pulmonary function or pulse oximetry tests have been obtained,forced expiratory volume of the lung in one second (FEV1) or forced vital capacity (FVC) are < 50% of predicted, or single breath diffusing capacity of the lung for carbon monoxide (DLCO) is < 35% of predicted or resting room oxygen saturation is less than 90%
  • No active or severe liver disease (e.g. acute or chronic hepatitis, cirrhosis)
  • No positive serology for anti-hemoglobin C (HBC) or anti-hepatitis C virus (HCV)antibodies; hepatitis B virus (HBV) seropositive patients (hepatitis B surface antigen[HBsAg] positive) are eligible if they are closely monitored for evidence of active HBV infection by HBV deoxryribonucleic acid (DNA) testing and agree to receive suppressive therapy with lamivudine or other HBV-suppressive therapy until at least 4 weeks after the last dose of everolimus
  • No New York Heart Association (NYHA) class >= 2 congestive heart failure
  • No active bleeding or chronic hemorrhagic diathesis or increased risk for bleeding:Including but not limited to history of major bleeding within 6 months (e.g.gastrointestinal, lung, CNS sites; or required transfusion support)
  • No history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to the initiation of treatment
  • No ongoing immunosuppressive therapy: including chronic systemic treatment with corticosteroids (>= 10 mg/day prednisone equivalent)
  • Archival tissue must be available for submission: though it is optional patients to choose to participate in the correlative substudies or not
  • Patients who are pregnant or nursing are not eligible
  • Women of child bearing potential must have a negative serum or urine pregnancy test within 16 days prior to registration
  • Women of child-bearing potential include:
  • Any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea >= 12 consecutive months)
  • Women on hormone replacement therapy (HRT) with documented serum follicle stimulating hormone (FSH) level > 35m IU/mL
  • Women who are using oral, implanted or injectable contraceptive hormones or mechanical products such as an intrauterine device or barrier methods(diaphragm, condoms, spermicides) to prevent pregnancy or practicing abstinence or where partner is sterile (e.g., vasectomy)
  • Performance status Eastern Cooperative Oncology Group (ECOG) 0-2 or Karnofsky score >=60%
  • Granulocytes >= 1,500/μL
  • Platelet count >= 100,000/μL
  • Calculated creatinine clearance >= 30 mL/minute (modified Cockroft and Gault formula)
  • Bilirubin =< 1.5 x upper limits of normal
  • Aspartate aminotransferase (AST) =< 2.5 x upper limits of normal (ULN)
  • Fasting serum triglycerides =< 200 mg/dL
  • Serum cholesterol =< 300 mg/dL
  • Fasting serum glucose =< 1.5 x ULN
  • Urine protein to creatinine ratio < 1.0 or urine protein =< 1+

Locations

  • Zuckerberg San Francisco General Hospital
    San Francisco California 94110 United States
  • UCSF Medical Center-Mount Zion
    San Francisco California 94115 United States
  • California Pacific Medical Center-Pacific Campus
    San Francisco California 94115 United States
  • Kaiser Permanente-San Francisco
    San Francisco California 94115 United States
  • Kaiser Permanente Cancer Treatment Center
    South San Francisco California 94080 United States
  • Kaiser Permanente-South San Francisco
    South San Francisco California 94080 United States
  • Kaiser Permanente-Fresno
    Fresno California 93720 United States
  • Bay Area Breast Surgeons Inc
    Emeryville California 94608 United States
  • Epic Care Partners in Cancer Care
    Emeryville California 94608 United States
  • Alta Bates Summit Medical Center - Summit Campus
    Oakland California 94609 United States
  • Bay Area Tumor Institute
    Oakland California 94609 United States
  • Hematology and Oncology Associates-Oakland
    Oakland California 94609 United States
  • Tom K Lee Inc
    Oakland California 94609 United States
  • Alta Bates Summit Medical Center-Herrick Campus
    Berkeley California 94704 United States
  • Highland General Hospital
    Oakland California 94602 United States
  • Kaiser Permanente-Richmond
    Richmond California 94801 United States
  • Mills-Peninsula Medical Center
    Burlingame California 94010 United States
  • Kaiser Permanente Oakland-Broadway
    Oakland California 94611 United States
  • Kaiser Permanente-Oakland
    Oakland California 94611 United States
  • Kaiser Permanente San Leandro
    San Leandro California 94577 United States
  • Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo California 94806 United States
  • Kaiser Permanente-San Rafael
    San Rafael California 94903 United States
  • East Bay Radiation Oncology Center
    Castro Valley California 94546 United States
  • Valley Medical Oncology Consultants-Castro Valley
    Castro Valley California 94546 United States
  • Contra Costa Regional Medical Center
    Martinez California 94553-3156 United States
  • Kaiser Permanente-Redwood City
    Redwood City California 94063 United States
  • Kaiser Permanente-Walnut Creek
    Walnut Creek California 94596 United States
  • Sutter Cancer Research Consortium
    Novato California 94945 United States
  • Kaiser Permanente-Vallejo
    Vallejo California 94589 United States
  • Sutter Solano Medical Center/Cancer Center
    Vallejo California 94589 United States
  • Kaiser Permanente-Fremont
    Fremont California 94538 United States
  • Valley Medical Oncology Consultants-Fremont
    Fremont California 94538 United States
  • El Camino Hospital
    Mountain View California 94040 United States
  • Kaiser Permanente Medical Center - Santa Clara
    Santa Clara California 95051 United States
  • Kaiser Permanente-Deer Valley Medical Center
    Antioch California 94531 United States
  • Rohnert Park Cancer Center
    Rohnert Park California 94928 United States
  • Kaiser Permanente Medical Center-Vacaville
    Vacaville California 95688 United States
  • Kaiser Permanente-Santa Teresa-San Jose
    San Jose California 95119 United States
  • Kaiser Permanente-Santa Rosa
    Santa Rosa California 95403 United States
  • Sutter Pacific Medical Foundation
    Santa Rosa California 95403 United States

Details

Status
in progress, not accepting new patients
Start Date
Sponsor
National Cancer Institute (NCI)
ID
NCT01198158
Phase
Phase 3
Study Type
Interventional
Last Updated
July 24, 2018