Summary

for people ages 50 years and up (full criteria)
at San Francisco, California
study started
estimated completion:
Marlene Grenon

Description

Summary

The hypothesis being tested is that in patients with stable claudication and documented PAD, omega-3 supplementation for 1 month will lead to improvement in endothelial function as measured by flow-mediated, brachial artery vasodilation (FMD), as well as improvement in the vascular inflammatory profile as measured by a panel of established circulating inflammatory biomarkers.

Keywords

Peripheral Arterial Disease Inflammation Peripheral Vascular Diseases Pro-Omega Omega 3 Fatty Acid

Eligibility

You can join if…

Open to people ages 50 years and up

  • intermittent claudication
  • resting or exercise Ankle-Brachial Index (ABI) <0.9
  • age 50 and more

You CAN'T join if...

  • critical limb ischemia
  • hypersensitivity/allergies to fish or seafood
  • already on omega-3 fatty acids or equivalent
  • significant renal, hepatic, and inflammatory disease
  • concurrent severe infections
  • acute illness (MI, stroke, major surgery within 30 days)
  • receiving immunosuppressive medications or steroids

Location

  • University of California San Francisco accepting new patients
    San Francisco California 94115 United States

Lead Scientist

  • Marlene Grenon
    Assoc Professor in Residence, Surgery. Authored (or co-authored) 64 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT01310270
Phase
Phase 2
Study Type
Interventional
Last Updated