for people ages 18 years and up (full criteria)
healthy people welcome
at San Francisco, California
study started
Ronald Miller, MD



The duration of the autonomic (sympathetic) block will last longer than the sensory block. The duration of the increased perfusion index will last longer than either the sympathetic or sensory block.


The Masimo SpHb™ (SpHb) is a device used to monitor the blood hemoglobin level via a sticky sensor connected to a finger. Our results from 2 recent studies undertaken with this device concluded: 1) that it is not always accurate when the finger is cold such as during surgical blood loss, and 2) a local nerve block to the finger improved the finger temperature and the accuracy of the device.

Our purpose is to investigate the duration of effect of two local nerve blocking drugs (lidocaine and bupivacaine - both FDA approved drugs in routine use) in a finger on each hand. Having a better understanding of how long the nerve block lasts could help determine when an additional block might be necessary to maintain the accuracy of the device during surgical blood loss.

We previously listed the primary outcome for this study as the time until return to baseline finger temperature. However, in blinded looks at the data it became clear that defining time until return to baseline from the serial temperature measurements in an objective fashion would be extremely difficult and potentially controversial. We have modified the primary outcome to be the change in the average temperature from baseline to post-intervention.


Onset and Duration of a Digital Nerve Block. Lidocaine Bupivacaine Lidocaine Digital Nerve Block Bupivacaine Digital Block


You can join if…

Open to people ages 18 years and up

  • Non-smokers

You CAN'T join if...

  • History of allergic response to local anesthetics
  • BMI >25
  • Pregnant of nursing
  • Current smokers or past smokers of > 1 pack year history
  • Neurological deficit and/or injury in the upper extremities
  • Current respiratory infection
  • Per investigator judgement, would not be suitable for study


  • University of California San Francisco
    San Francisco California 94143 United States

Lead Scientist

  • Ronald Miller, MD
    Professor Emeritus, Anesthesia. Authored (or co-authored) 13 research publications


currently not accepting new patients, but might later
Start Date
University of California, San Francisco
Phase 4
Study Type
Last Updated