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for people ages up to 18 years (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



The overarching objective is to develop new evidence-based treatment guidelines for invasive fungal diseases in children. To accomplish that, this protocol will focus on two specific aims: 1) Compare the effectiveness of echinocandin versus amphotericin B or triazole antifungal therapy for pediatric invasive candidiasis and for the subset of patients with invasive candidemia; 2) Characterize the incidence rate of inpatient pediatric invasive candidiasis per hospital admissions.

Official Title

International Pediatric Fungal Network: Multi-Center Studies to Improve Diagnosis and Treatment of Pediatric Candidiasis


This study is a multicenter, national and international, prospective observational comparative effectiveness study.

The primary aim of this study is to compare the effectiveness of echinocandin versus amphotericin B or triazole antifungal therapy for pediatric invasive candidiasis and for invasive candidemia. The primary effectiveness endpoint for study aim 1 is the comparison of global response at 14 days of antifungal therapy between antifungal therapeutic classes. The secondary effectiveness endpoints for study aim 1 are comparative effectiveness of the 1) global response to antifungal therapy after 30 days and 2) all-cause mortality at 30 days.

The secondary aim is to characterize the frequency of pediatric candidiasis by describing the incidence of pediatric candidiasis relative to all pediatric admissions. For this aim, the investigators will use descriptive statistics to establish the frequency of hospital admissions involving an invasive candidiasis per total hospital admissions and total hospital days during the study period.


Pediatric Invasive Candidiasis Candida Pediatric Antifungal Candidiasis Candidiasis, Invasive Antifungal Agents Miconazole


You can join if…

Open to people ages up to 18 years

  1. Males or females age > 120 days and <18 years
  2. Documented proven or probable case of invasive candidiasis
  3. Parental/guardian permission (informed consent, if required) and if appropriate, child assent (if required).

You CAN'T join if...

1) Any history of prior Candida infection within the previous 35 days (These patients will not be eligible for analysis in aim 1 but will be eligible for inclusion of aim 2)


  • UCSF Benioff Children's Hospital accepting new patients
    San Francisco, California, United States
  • Lucile Packard Children's Hospital at Stanford accepting new patients
    Palo Alto, California, United States
  • Children's Hospital of Orange County accepting new patients
    Orange, California, United States


accepting new patients
Start Date
Completion Date
Duke University
International Pediatric Fungal Network
Study Type
Observational [Patient Registry]
Last Updated
July 11, 2017
I’m interested in this study!