for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.

Official Title

An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Patients Undergoing Cardiac Surgery


Disorder; Heart, Functional, Postoperative, Cardiac Surgery Cardiac Surgery Transfusion Restrictive Transfusion Strategy Liberal transfusion strategy


You can join if…

Open to people ages 18 years and up

  • Age 18 or older
  • Planned cardiac surgery using cardiopulmonary bypass
  • Informed consent obtained
  • Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

You CAN'T join if...

  • Patients who are unable to receive or who refuse blood products
  • Patients who are involved in a preoperative autologous pre-donation program
  • Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
  • Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential.)
  • Patients who are unable to receive or who refuse blood products


  • San Francisco VA Medical Center
    San Francisco California 94121 United States
  • Kelowna General Hospital
    Kelowna British Columbia V1Y 1T2 Canada
  • Vancouver General Hospital
    Vancouver British Columbia V5Z 1L7 Canada
  • Foothills Medical Centre
    Calgary Alberta T2N 2T9 Canada
  • University of Alberta
    Edmonton Alberta T6G 2R3 Canada
  • University of Texas Southwestern Medical Center
    Dallas Texas 75235 United States
  • St Boniface Hospital
    Winnipeg Manitoba R2H 2A6 Canada
  • Baylor College of Medicine
    Houston Texas 77030 United States
  • Michael E. DeBakey Veterans Affairs Medical Center
    Houston Texas 77030 United States


in progress, not accepting new patients
Start Date
Completion Date
St. Michael's Hospital, Toronto
Study Type
Last Updated
September 22, 2017