for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.

Official Title

An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Patients Undergoing Cardiac Surgery


Disorder; Heart, Functional, Postoperative, Cardiac Surgery Cardiac Surgery Transfusion


You can join if…

Open to people ages 18 years and up

  • Age 18 or older
  • Planned cardiac surgery using cardiopulmonary bypass
  • Informed consent obtained
  • Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

You CAN'T join if...

  • Patients who are unable to receive or who refuse blood products
  • Patients who are involved in a preoperative autologous pre-donation program
  • Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
  • Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential.)
  • Patients who are unable to receive or who refuse blood products


  • San Francisco VA Medical Center
    San Francisco, California, 94121, United States
  • Kelowna General Hospital
    Kelowna, British Columbia, V1Y 1T2, Canada
  • Vancouver General Hospital
    Vancouver, British Columbia, V5Z 1L7, Canada
  • Foothills Medical Centre
    Calgary, Alberta, T2N 2T9, Canada
  • University of Alberta
    Edmonton, Alberta, T6G 2R3, Canada
  • University of Texas Southwestern Medical Center
    Dallas, Texas, 75235, United States
  • St Boniface Hospital
    Winnipeg, Manitoba, R2H 2A6, Canada
  • Baylor College of Medicine
    Houston, Texas, 77030, United States
  • Michael E. DeBakey Veterans Affairs Medical Center
    Houston, Texas, 77030, United States
  • Hamilton General Hospital
    Hamilton, Ontario, L8L 2X2, Canada
  • Kingston General Hospital
    Kingston, Ontario, K7L 2V7, Canada
  • London Health Sciences Center
    London, Ontario, N6G 2V4, Canada
  • Southlake Regional Health Centre
    Newmarket, Ontario, L3Y 2P9, Canada
  • University of Ottawa Heart Institute
    Ottawa, Ontario, K1Y 4W7, Canada
  • Sunnybrook Health Sciences Centre
    Toronto, Ontario, M4N 3M5, Canada
  • St Michael's Hospital
    Toronto, Ontario, M5B1W8, Canada
  • University Health Network Toronto General Hospital
    Toronto, Ontario, M5G 2C4, Canada
  • Durham Veterans Affairs Medical Center
    Durham, North Carolina, 27705, United States
  • Montefiore Medical Center
    The Bronx, New York, 10467, United States
  • Yale-New Haven Hospital
    New Haven, Connecticut, 06510-3202, United States
  • Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)
    Chemin Sainte-Foy, Quebec, G1V 4G5, Canada
  • SMBD Jewish General Hospital
    Montreal, Quebec, H3T 1E2, Canada
  • Hôpital du Sacré-Cœur de Montréal
    Montreal, Quebec, H4J 1C5, Canada
  • Centre hospitalier de l'Université de Montréal
    Montreal, Quebec, Canada
  • Montreal Heart Institute
    Montréal, Quebec, H1T 1C8, Canada
  • Centre Hospitalier Universitaire de Sherbrooke
    Sherbrooke, Quebec, J1G 2E8, Canada
  • Maine Medical Center
    Portland, Maine, United States
  • Saint John Regional Hospital
    Saint John, New Brunswick, E2L 4L4, Canada
  • QEII Health Science Centre
    Halifax, Nova Scotia, B3H 2Y9, Canada
  • Health Sciences Centre (Memorial University)
    St John's, Newfoundland and Labrador, A1B 3X9, Canada
  • Instituto del Corazón de Bucaramanga
    Bucaramanga, Santander, Colombia
  • Clinica de Marly
    Bogota, Colombia
  • Fundacion Cardioinfantil Instituto de Cardiologia
    Bogota, Colombia
  • Fundación Clínica Shaio
    Bogota, Colombia
  • Hospital De San Jose
    Bogota, Colombia
  • Hospital Unimed Rio (National Institute of Cardiology)
    Rio de Janeiro, Brazil
  • Rigshospitalet - Copenhagen University Hospital
    Copenhagen, 2100, Denmark
  • Charité - Universitätsmedizin Berlin
    Berlin, 10117, Germany
  • University Hospital Giessen
    Giessen, Germany
  • Hospital de la Santa Creu i Sant Pau
    Barcelona, Spain
  • Hospital Ramón y Cajal
    Madrid, Spain
  • Consorcio Hospital General Universitario de Valencia
    Valencia, 46014, Spain
  • Instituto de Investigación Sanitaria Hospital Univ. & Politc. La Fe de Valencia
    Valencia, 46026, Spain
  • University Hospital Basel
    Basel, 4056, Switzerland
  • University Hospital Bern (Inselspital)
    Bern, Switzerland
  • Emergency Institute for Cardiovascular Diseases
    Târgu-Mureș, Romania
  • Shanghai Yodak Cardio-Thoracic Hospital
    Shanghai, 200235, China
  • Renji Hospital
    Shanghai, China
  • University of Thessaly
    Volos, Greece
  • Auckland City Hospital
    Auckland, 1023, New Zealand
  • Christchurch Hospital
    Christchurch, 4710, New Zealand
  • Dunedin Hospital
    Dunedin, 9016, New Zealand
  • Waikato Hospital
    Hamilton, 3204, New Zealand
  • Wellington Hospital
    Wellington, 6021, New Zealand
  • Sheba Medical Center
    Ramat Gan, 5262100, Israel
  • Tel Aviv Sourasky Medical Centre
    Tel Aviv, 64239, Israel
  • Tanta University Hospital
    Tanta, Egypt
  • Royal Prince Alfred Hospital
    Camperdown, New South Wales, 2050, Australia
  • Royal North Shore Hospital
    Sydney, New South Wales, 2065, Australia
  • Westmead Hospital
    Westmead, New South Wales, 2145, Australia
  • Royal Adelaide Hospital
    Adelaide, South Australia, 5000, Australia
  • Flinders Medical Centre
    Bedford Park, South Australia, 5042, Australia
  • Monash Medical Centre
    Clayton, Victoria, 3168, Australia
  • St Vincent's Hospital, Melbourne
    Fitzroy, Victoria, 3065, Australia
  • Austin Hospital
    Heidelberg, Victoria, 3084, Australia
  • Cabrini Health
    Malvern, Victoria, 3144, Australia
  • Alfred Hospital
    Melbourne, Victoria, 3004, Australia
  • Barwon Health (University Hospital Geelong)
    Melbourne, Victoria, 3220, Australia
  • Royal Melbourne Hospital
    Parkville, Victoria, 3050, Australia
  • Institut Jantung Negara
    Kuala Lampur, 50400, Malaysia
  • Narayana Health
    Bangalore, Karnataka, India
  • SAL Hospital
    Gujarat, 380054, India
  • National Heart Centre Singapore
    Singapore, Singapore
  • University of KwaZulu-Natal
    Durban, KwaZulu-Natal, 4041, South Africa


in progress, not accepting new patients
Start Date
Completion Date
St. Michael's Hospital, Toronto
Study Type
Last Updated
September 22, 2017