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Summary

for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:

Description

Summary

TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.

Official Title

An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Patients Undergoing Cardiac Surgery

Keywords

Disorder; Heart, Functional, Postoperative, Cardiac Surgery Cardiac Surgery Transfusion

Eligibility

You can join if…

Open to people ages 18 years and up

  • Age 18 or older
  • Planned cardiac surgery using cardiopulmonary bypass
  • Informed consent obtained
  • Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

You CAN'T join if...

  • Patients who are unable to receive or who refuse blood products
  • Patients who are involved in a preoperative autologous pre-donation program
  • Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
  • Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential.)
  • Patients who are unable to receive or who refuse blood products

Locations

  • San Francisco VA Medical Center
    San Francisco, California, 94121, United States
  • Vancouver General Hospital
    Vancouver, British Columbia, V5Z 1L7, Canada
  • Kelowna General Hospital
    Kelowna, British Columbia, V1Y 1T2, Canada
  • Foothills Medical Centre
    Calgary, Alberta, T2N 2T9, Canada
  • University of Alberta
    Edmonton, Alberta, T6G 2R3, Canada
  • University of Texas Southwestern Medical Center
    Dallas, Texas, 75235, United States
  • St Boniface Hospital
    Winnipeg, Manitoba, R2H 2A6, Canada
  • Baylor College of Medicine
    Houston, Texas, 77030, United States
  • Michael E. DeBakey Veterans Affairs Medical Center
    Houston, Texas, 77030, United States
  • London Health Sciences Center
    London, Ontario, N6G 2V4, Canada
  • Hamilton General Hospital
    Hamilton, Ontario, L8L 2X2, Canada
  • Southlake Regional Health Centre
    Newmarket, Ontario, L3Y 2P9, Canada
  • Sunnybrook Health Sciences Centre
    Toronto, Ontario, M4N 3M5, Canada
  • St Michael's Hospital
    Toronto, Ontario, M5B1W8, Canada
  • University Health Network Toronto General Hospital
    Toronto, Ontario, M5G 2C4, Canada
  • Durham Veterans Affairs Medical Center
    Durham, North Carolina, 27705, United States
  • Kingston General Hospital
    Kingston, Ontario, K7L 2V7, Canada
  • University of Ottawa Heart Institute
    Ottawa, Ontario, K1Y 4W7, Canada
  • Hôpital du Sacré-Cœur de Montréal
    Montreal, Quebec, H4J 1C5, Canada
  • SMBD Jewish General Hospital
    Montreal, Quebec, H3T 1E2, Canada
  • Montreal Heart Institute
    Montréal, Quebec, H1T 1C8, Canada
  • Montefiore Medical Center
    The Bronx, New York, 10467, United States
  • Yale-New Haven Hospital
    New Haven, Connecticut, 06510-3202, United States
  • Centre Hospitalier Universitaire de Sherbrooke
    Sherbrooke, Quebec, J1G 2E8, Canada
  • Centre hospitalier de l'Université de Montréal
    Montreal, Quebec, Canada
  • Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)
    Chemin Sainte-Foy, Quebec, G1V 4G5, Canada
  • Maine Medical Center
    Portland, Maine, United States
  • Saint John Regional Hospital
    Saint John, New Brunswick, E2L 4L4, Canada
  • QEII Health Science Centre
    Halifax, Nova Scotia, B3H 2Y9, Canada
  • Health Sciences Centre (Memorial University)
    St John's, Newfoundland and Labrador, A1B 3X9, Canada
  • Instituto del Corazón de Bucaramanga
    Bucaramanga, Santander, Colombia
  • Clinica de Marly
    Bogota, Colombia
  • Fundacion Cardioinfantil Instituto de Cardiologia
    Bogota, Colombia
  • Fundación Clínica Shaio
    Bogota, Colombia
  • Hospital De San Jose
    Bogota, Colombia
  • Hospital Unimed Rio (National Institute of Cardiology)
    Rio de Janeiro, Brazil
  • Rigshospitalet - Copenhagen University Hospital
    Copenhagen, 2100, Denmark
  • Charité - Universitätsmedizin Berlin
    Berlin, 10117, Germany
  • University Hospital Giessen
    Giessen, Germany
  • Hospital de la Santa Creu i Sant Pau
    Barcelona, Spain
  • Hospital Ramón y Cajal
    Madrid, Spain
  • Consorcio Hospital General Universitario de Valencia
    Valencia, 46014, Spain
  • Instituto de Investigación Sanitaria Hospital Univ. & Politc. La Fe de Valencia
    Valencia, 46026, Spain
  • University Hospital Basel
    Basel, 4056, Switzerland
  • University Hospital Bern (Inselspital)
    Bern, Switzerland
  • Emergency Institute for Cardiovascular Diseases
    Târgu-Mureș, Romania
  • Shanghai Yodak Cardio-Thoracic Hospital
    Shanghai, 200235, China
  • Renji Hospital
    Shanghai, China
  • University of Thessaly
    Volos, Greece
  • Auckland City Hospital
    Auckland, 1023, New Zealand
  • Christchurch Hospital
    Christchurch, 4710, New Zealand
  • Dunedin Hospital
    Dunedin, 9016, New Zealand
  • Waikato Hospital
    Hamilton, 3204, New Zealand
  • Wellington Hospital
    Wellington, 6021, New Zealand
  • Sheba Medical Center
    Ramat Gan, 5262100, Israel
  • Tel Aviv Sourasky Medical Centre
    Tel Aviv, 64239, Israel
  • Tanta University Hospital
    Tanta, Egypt
  • Royal Prince Alfred Hospital
    Camperdown, New South Wales, 2050, Australia
  • Royal North Shore Hospital
    Sydney, New South Wales, 2065, Australia
  • Westmead Hospital
    Westmead, New South Wales, 2145, Australia
  • Royal Adelaide Hospital
    Adelaide, South Australia, 5000, Australia
  • Flinders Medical Centre
    Bedford Park, South Australia, 5042, Australia
  • Monash Medical Centre
    Clayton, Victoria, 3168, Australia
  • St Vincent's Hospital, Melbourne
    Fitzroy, Victoria, 3065, Australia
  • Austin Hospital
    Heidelberg, Victoria, 3084, Australia
  • Cabrini Health
    Malvern, Victoria, 3144, Australia
  • Alfred Hospital
    Melbourne, Victoria, 3004, Australia
  • Barwon Health (University Hospital Geelong)
    Melbourne, Victoria, 3220, Australia
  • Royal Melbourne Hospital
    Parkville, Victoria, 3050, Australia
  • Institut Jantung Negara
    Kuala Lampur, 50400, Malaysia
  • Narayana Health
    Bangalore, Karnataka, India
  • SAL Hospital
    Gujarat, 380054, India
  • University of KwaZulu-Natal
    Durban, KwaZulu-Natal, 4041, South Africa
  • National Heart Centre Singapore
    Singapore, Singapore

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
St. Michael's Hospital, Toronto
ID
NCT02042898
Study Type
Interventional
Last Updated
September 22, 2017