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Nicotine clinical trials at UCSF

6 in progress, 3 open to eligible people

Showing trials for
  • Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

    open to eligible people ages 21-70

    This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.

    San Francisco, California

  • Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

    open to eligible people ages 21-70

    This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21). The specific aim of the study is to assess the impact of changes in e-liquid pH on nicotine pharmacokinetics, cardiovascular, and subjective effects of e-cigarettes.

    San Francisco, California and other locations

  • THC Crossover Study

    open to eligible people ages 21 years and up

    This is a randomized, crossover study enrolling experienced dual cannabis-tobacco smokers (N=18) to describe the differences in THC and toxicant exposure, examining pharmacokinetic, subjective, and cardiovascular effects from smoking and vaping dry herb cannabis. This study will also examine the differences in toxicant exposure and cardiovascular disease risk between smoking cannabis and smoking tobacco cigarettes.

    San Francisco, California and other locations

  • Pharmacodynamics of Synthetic Nicotine

    Sorry, not yet accepting patients

    In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

    San Francisco, California

  • Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

    Sorry, in progress, not accepting new patients

    Social media based intervention to support teens in their efforts to quit vaping.

    San Francisco, California

  • Clinical Pharmacology of Marijuana-Tobacco Co-administration

    Sorry, not yet accepting patients

    This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.

    San Francisco, California

Our lead scientists for Nicotine research studies include .

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