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for females ages 18–60 (full criteria)
healthy people welcome
at San Francisco, California
study started
estimated completion:



Randomized controlled clinical trial of IV nitroglycerin at cesarean delivery for second stage arrest of descent to prevent or uterine extension at the hysterectomy site.

Official Title

Randomized Controlled Trial of IV Nitroglycerin in Cesarean Deliveries After Second Stage Arrest for the Prevention of Uterine Extension


Intravenous nitroglycerin resulting in uterine relaxation has been standardly utilized for various obstetrics conditions, e.g. breech extraction of second twin in vaginal deliveries, uterine relaxation after tachysystole in labor, prior to external cephalic version, and during difficult fetal extraction during cesarean delivery for arrest of descent in labor. Currently the use of nitroglycerin is at equipoise in obstetrics for difficult cesarean delivery after second stage arrest in labor. The clinical trial will randomize women who undergo cesarean delivery for second stage arrest in labor to receive IV nitroglycerin vs saline at the time of hysterotomy. The primary outcomes will be maternal: uterine extension, blood loss, total fetal extraction time, surgical time; neonatal: cord gases at delivery, apgar scores, admission to neonatal intensive care unit.


Prolonged Second Stage of Labor Nitroglycerin


You can join if…

Open to females ages 18–60

women 37weeks or greater gestation diagnosed with second stage arrest of descent undergoing cesarean delivery -

You CAN'T join if...

elective, active phase arrest cesarean delivery, successful operative vaginal delivery


  • University California San Francisco-Labor and Delivery accepting new patients
    San Francisco, California, 94143, United States


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Phase 4
Lead Scientist
Jennifer Lucero
Study Type
Last Updated
November 2016
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