for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Jennifer Lai



The purpose of this study is to learn more about the effects of exercise on functional status and outcomes on patients with end-stage liver disease on the liver transplant waiting list and who have undergone liver transplantation.


This study aims to evaluate the effects of a home-based exercise intervention on outcomes in liver transplant candidates and recipients. This home-based intervention consists of a 30-minute exercise session available on digital video disc or on the internet. This intervention was originally developed to improve functional status in community-dwelling older adults and therefore, has been designed to maximize the safety for even the most frail individuals. Subjects enrolled in this study will be randomized to one of two arms: (a) the exercise intervention arm in which the subjects will be asked perform this exercise session three to four times per week or (b) the standard-of-care arm in which the patient will be encouraged to exercise by their transplant clinician at every clinic visit. Subjects in the exercise intervention arm will undergo this intervention for 6 months. All subjects will be followed for up to two years from the time of enrollment to ascertain outcomes.


End Stage Liver Disease Sarcopenia Liver Cirrhoses Liver Transplantation Liver Diseases Liver Cirrhosis Exercise Program


You can join if…

Open to people ages 18 years and up

  • Adult (>=18 years of age)
  • Listed for liver transplantation or post-liver transplantation
  • English speaking

You CAN'T join if...

  • Contraindications to weight-bearing exercise
  • Non-English speaking
  • Requires an assistive device for ambulation
  • Active hepatic encephalopathy at the time of baseline assessment for enrollment in the study


  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States
  • Duke University accepting new patients
    Durham North Carolina 27708 United States

Lead Scientist

  • Jennifer Lai
    Dr. Lai is a general and transplant hepatologist who specializes in caring for patients with chronic viral hepatitis, autoimmune disorders, and cirrhosis, particularly those awaiting liver transplantation. Her academic mission is to improve the lives of patients with end-stage liver disease through the application of core principles of geriatrics into the care of patients with cirrhosis.


accepting new patients
Start Date
Completion Date
University of California, San Francisco
National Center for Health Statistics
United Network for Organ Sharing
Study Type
Last Updated