for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



MGCD265 is an orally administered receptor tyrosine kinase inhibitor that targets MET and other receptors. This study is a Phase 2 trial of MGCD265 in patients with locally advanced, unresectable or metastatic non-small cell lung cancer (NSCLC) that has activating genetic changes of the MET gene (mutation or amplification [increase number of gene copies]). Testing for tumor gene changes can be performed in tumor tissue or blood samples. Patients must have previously received treatment with chemotherapy. The number of patients to be enrolled will depend on how many enrolled patients experience tumor size reduction. MGCD265 will be administered orally, twice daily. The study is designed to evaluate whether the number of patients experiencing tumor size reduction is substantially higher than would be expected with other available treatments.

Official Title

Phase 2, Parallel-Arm Study of MGCD265 in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Activating Genetic Alterations in Mesenchymal-Epithelial Transition Factor


If testing has not already been performed, the study will provide for the testing.


Non-Small Cell Lung Cancer Mirati MGCD265 MET NSCLC Lung Neoplasms Carcinoma, Non-Small-Cell Lung


You can join if…

Open to people ages 18 years and up

  • Diagnosis of non-small cell lung cancer
  • Metastatic or locally advanced disease
  • Prior platinum chemotherapy or immunotherapy
  • Test result showing genetic change in MET tumor gene
  • At least one tumor that can be measured on a radiographic scan

You CAN'T join if...

  • Prior treatment with inhibitor of MET or HGF
  • Prior positive test for EGFR mutation or ALK gene rearrangement
  • Uncontrolled tumor in the brain


  • University of California, San Francisco
    San Francisco California 94143 United States
  • Providence Saint Joseph Medical Center
    Burbank California 91505 United States


in progress, not accepting new patients
Start Date
Completion Date
Mirati Therapeutics Inc.
Phase 2
Study Type
Last Updated