for people ages 60-85 (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Allison Kaup



The purpose of this study is to conduct a pilot trial investigating cognitive training in older Veterans with a history of traumatic brain injury (TBI) to assess training effects, acceptability of training to participants, and to explore whether other factors influence training effects.

Official Title

Cognitive Reserve and Training in Older Veterans With Traumatic Brain Injury: Study 2


A study of older Veterans (60-85 years old) who have 1) a history of repetitive mild TBI or at least one moderate TBI and 2) subjective cognitive complaints. Participants will be randomized to one of three conditions for 4 weeks: Project:Evolution (EVO) multitask video game, EVO words video game, or an assessment only control condition. Participants will complete assessment visits at baseline, post-intervention (1 month after baseline), and 3 months post-intervention (4 months after baseline).


TBI (Traumatic Brain Injury)traumatic brain injury (TBI)agingcognitive trainingCognitive AgingWounds and InjuriesBrain InjuriesBrain Injuries, TraumaticEVO multitask video gameEVO words video gameAssessment Only


You can join if…

Open to people ages 60-85

  1. Ages 60-85
  2. Have experienced more than one mild TBI or at least one moderate TBI over their lifetime
  3. Have current cognitive problems based on self-report
  4. Vision adequate to see test stimuli
  5. Hearing adequate to understand the examiner
  6. Fluent in English in order to understand task instructions
  7. Demonstrate capacity to consent to participate in research
  8. Mini-Mental Status Exam (MMSE) score ≥ 25

You CAN'T join if...

  1. History of penetrating brain injury
  2. Active disabling neurological condition (e.g., stroke, brain tumor, multiple sclerosis)
  3. History of severe psychiatric illness (i.e., schizophrenia, bipolar disorder, schizoaffective disorder)
  4. Active drug use or active heavy alcohol use
  5. History of severe TBI
  6. History of a dementia diagnosis
  7. Individuals who are physically unable to use an iPad for 30 minutes at a time per day will be excluded, such as individuals with debilitating arthritis or tremor


  • San Francisco VA Medical Center
    San FranciscoCalifornia94121United States
  • Veterans Home of California
    YountvilleCalifornia94599United States

Lead Scientist

  • Allison Kaup
    Dr. Allison Kaup is a neuropsychologist and researcher who studies cognitive aging. Her research has included investigations of dementia risk factors, factors that protect against cognitive decline in aging, and neural correlates of cognitive aging. Dr. Kaup is particularly interested in understanding the role of cognitive reserve in protecting the aging brain.


in progress, not accepting new patients
Start Date
Completion Date
San Francisco Veterans Affairs Medical Center
Study Type
Last Updated