for people ages 40 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Stephen Lazarus



Symptoms of chronic obstructive pulmonary disease (COPD) and high body mass index (BMI) overlap. The investigators are trying to find out if a program proven to help people lose a modest amount of weight and increase their physical activity will improve COPD symptoms for those with a high BMI. The program uses a series of digital video discs (DVD) sessions focused on healthy eating and physical activity, and encourages participants to monitor their weight, diet, and physical activity for two years. For those who want to, they will be able to work with a health coach to help meet weight and activity goals. We hope that the program will lead to weight loss, better exercise tolerance, and less shortness of breath. To be in the study, participants will need to have COPD, high BMI, history of smoking, shortness of breath, and be at least 40 years old.


Pulmonary Disease, Chronic ObstructiveObesityWeight LossLife StyleOverweightrandomized controlled trialdietexercisechronic obstructive pulmonary diseaselifestyleLung DiseasesChronic DiseaseLifestyle Intervention


You can join if…

Open to people ages 40 years and up

  • 40 years or older at time of eligibility screening;
  • Body mass index 25.0-44.9 kg/m2 (also see Figure 2);
  • Smoked more than 10 pack-years of cigarettes;
  • Shortness of breath;
  • COPD;
  • Able to participate fully in all study protocol/procedures including written informed consent process.

You CAN'T join if...

  • Inability to speak, read, or understand English;
  • Active weight loss interventions;
  • Expected weight loss because of alternate explanations, such as from illness;
  • Unable to ambulate to weight scale for weight measurement;
  • Safety and/or adherence concerns due to severe physical or mental health issues or life expectancy <24 months;
  • Pregnant, lactating, or planning to become pregnant during the study period;
  • Participation in other intervention studies.


  • Universtiy of California, San Francisco accepting new patients
    San FranciscoCalifornia94143United States
  • University of California, Los Angeles accepting new patients
    Los AngelesCalifornia90095United States

Lead Scientist

  • Stephen Lazarus
    Dr. Lazarus is an inbred product of the University of California, having received his A.B. from Berkeley, his M.D. from Irvine, and training in Internal Medicine and Pulmonary & Critical Care Medicine at UCSF. Drafted into military service during the Viet Nam era, he spent 2 years as Chief of Pulmonary Medicine and Co-Director of the ICU at Andrews Air Force Base in Washington, D.C.


accepting new patients
Start Date
Completion Date
Seattle Institute for Biomedical and Clinical Research
Study Type
Last Updated