for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion
Michael Evans



This is a single center imaging study investigating the use of PET with 68Ga-citrate in patients with DLBCL or BCLU.


This is a single center feasibility imaging study in patients with diffuse large B-cell lymphoma (DLBCL) or B-cell Lymphoma, Unclassifiable with features between DLBCL and Burkitt's (BCLU). Study participants will undergo PET/MRI of the whole body with 68Ga citrate.

The study will include at least 5 patients with double hit lymphoma and 5 patients with DLBCL with an additional 5 more patients as expansion once the dose level has been established. Patients with DLBCL will be included once an optimal dose level for the resolution of cancer lesions has been established.


Lymphoma, Large B-Cell, Diffuse Burkitt Lymphoma lymphoma gallium citrate PET Lymphoma, B-Cell Citric Acid Sodium Citrate


You can join if…

Open to people ages 18 years and up

  1. Histologically confirmed DLBCL or BCLU.
  2. Double hit lymphoma, defined by positive cytogenetic/FISH analysis for translocations involving myc and bcl2 or a double hit score of 2 by immunohistochemistry as described by Johnson et al.
  3. DLBCL without myc translocation or overexpression by the above methods
  4. Presence of palpable or radiographically measurable disease of at least 1.5 cm in longest dimension.
  5. Available prior CT or PET/CT scan done in the last 8 weeks for comparison
  6. Prior chemotherapy or radiation to the measurable lesion must be completed at least 14 days prior.
  7. Adequate renal function with estimated creatinine clearance ≥50 mL/min (by the Cockcroft Gault equation)
  8. No contraindications to MRI (e.g. pacemaker, aneurysm clips, severe claustrophobia)
  9. Ability to sign a study-specific IRB-approved consent prior to study entry. Patients must be able and willing to consent and undergo study procedures.
  10. Age ≥18 years old

You CAN'T join if...

  1. Any serious and/or unstable pre-existing medical, psychiatric, or other medical condition that could interfere with subject's safety, provision of informed consent, or compliance with study procedures
  2. Body weight over 300 pounds
  3. Female patients who are pregnant or breast-feeding
  4. Prior MRI with gadolinium performed <24 hours before the study scan
  5. No red blood cell transfusion or iron administration by any route in the last 7 days
  6. Prior hypersensitivity or intolerance to gadolinium or gallium citrate.


  • UCSF Helen Diller Family Comprehensive Cancer Center accepting new patients
    San Francisco California 94143 United States

Lead Scientist


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated