for people ages 13 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Principal Investigator
by Michael A. Matthay, MD
Photo of Michael A. Matthay
Michael A. Matthay



The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional ventilatory strategy.


Deceased organ donors are maintained on life support including mechanical ventilation during the time between brain death and organ procurement. The optimal mode of mechanical ventilation for deceased organ donors has not been definitively established. Since deceased organ donors may develop atelectasis leading to impaired oxygenation, an open lung protective ventilatory strategy with higher positive end expiratory pressure (PEEP), lower tidal volume and recruitment maneuvers has been hypothesized to be beneficial. Favorable outcomes were observed in a European clinical trial comparing open lung protective ventilation (OLPV) to a conventional ventilatory strategy in terms of donor oxygenation and lung utilization for transplantation (Mascia L et al, Journal of the American Medical Association 2010). However, donor management procedures in Europe are much shorter in duration compared to the US and it is not clear that these findings are generalizable to the US donor management environment. The GOLD trial will test the effect of an OLPV strategy compared to conventional ventilation (CV) in the US donor management environment. This multi center trial will enroll 400 brain dead organ donors randomized into 1 of 2 treatment arms. After randomization, mechanical ventilation will be protocolized according to treatment arm with one arm receiving control ventilation (CV) utilizing standard Donor Network West (DNW) protocols and the other arm receiving the OLPV strategy with higher positive end expiratory pressure (PEEP) and lower tidal volume compared to CV. The primary outcomes is donor lung utilization for transplantation.


Brain Death Organ Donation Organ Transplant Failure or Rejection Open lung protective ventilation


You can join if…

Open to people ages 13 years and up

  • Brain death
  • Authorization for research
  • ≥13 years of age

You CAN'T join if...

  • Arterial/Inspired oxygen ratio (PaO2/FiO2) ≤ 150 mmHg
  • PaO2/FiO2 ≥ 400 mmHg
  • BMI > 40
  • Hepatitis B surface antigen positive
  • Hepatitis C positive
  • Failure to complete donation process
  • Hemodynamic instability


  • University of California San Francisco accepting new patients
    San Francisco California 94143 United States
  • Donor Network West accepting new patients
    San Ramon California 94583 United States
  • Stanford University accepting new patients
    Palo Alto California 94305 United States

Lead Scientist at UCSF

  • Michael A. Matthay, MD
    Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.


accepting new patients
Start Date
Completion Date
Vanderbilt University Medical Center
Study Type
Last Updated