Summary

for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion:
Pekka Talke

Description

Summary

Spontaneous myogenic oscillations will be studied under general anesthesia using finger photoplethysmography. This pilot study will explore potential physiological conditions that will effect the amplitude and/or frequency of myogenic oscillations.

Official Title

A Pilot Study to Evaluate the Effect of Changing Physiological Conditions on the Amplitude and/or Frequency of Myogenic Oscillations

Details

This is a single center, nonrandomized, nonblinded, interventional clinical pilot research study that plans to enroll 40 patients.

Study will be conducted while subjects are under general anesthesia.

Myogenic oscillations will be measured using finger photoplethysmography. Changes in the amplitude and/or frequency of these oscillations will be analyzed in response to the interventions. Arterial blood pressure will be recorded to verify the efficacy of the interventions.

Six different interventions that will either lower or increase blood pressure will be applied to the subjects. Each subject will receive 1 or 2 of the six interventions. Each of the 6 interventions will be applied to 8 subject.

The interventions that the subject will not be randomized. They will be determined by the subjects blood pressure immediately before the intervention to guarantee that the blood pressure manipulations are within a safe range.

Data will be analyzed offline using Matlab.

Keywords

Vascular Diseases Calcium, Dietary Dexmedetomidine Phenylephrine Oxymetazoline Clevidipine tetanic stimulus Increased venous pressure Calcium Chloride

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Over 18 yrs of age
  2. Undergoing surgery in Moffitt-Long operating rooms
  3. Receiving general anesthesia
  4. Will have an intra-arterial catheter for clinical purposes
  5. Able to consent in english

You CAN'T join if...

  1. Under 18 years of age
  2. unable to provide informed consent
  3. Pregnancy

Location

  • University of California San Francisco accepting new patients
    San Francisco California 94122 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT03719001
Phase
Phase 1
Lead Scientist
Pekka Talke
Study Type
Interventional
Last Updated