for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion
Principal Investigator
by Pekka Talke, MD



Spontaneous myogenic oscillations will be studied under general anesthesia using finger photoplethysmography. This pilot study will explore potential physiological conditions that will effect the amplitude and/or frequency of myogenic oscillations.

Official Title

A Pilot Study to Evaluate the Effect of Changing Physiological Conditions on the Amplitude and/or Frequency of Myogenic Oscillations


This is a single center, nonrandomized, nonblinded, interventional clinical pilot research study that plans to enroll 40 patients. Study will be conducted while subjects are under general anesthesia. Myogenic oscillations will be measured using finger photoplethysmography. Changes in the amplitude and/or frequency of these oscillations will be analyzed in response to the interventions. Arterial blood pressure will be recorded to verify the efficacy of the interventions. Six different interventions that will either lower or increase blood pressure will be applied to the subjects. Each subject will receive 1 or 2 of the six interventions. Each of the 6 interventions will be applied to 8 subject. The interventions that the subject will not be randomized. They will be determined by the subjects blood pressure immediately before the intervention to guarantee that the blood pressure manipulations are within a safe range. Data will be analyzed offline using Matlab.


Vascular Diseases Clevidipine Phenylephrine Oxymetazoline Dexmedetomidine Calcium tetanic stimulus Increased venous pressure Calcium Chloride


You can join if…

Open to people ages 18 years and up

  1. Over 18 yrs of age
  2. Undergoing surgery in Moffitt-Long operating rooms
  3. Receiving general anesthesia
  4. Will have an intra-arterial catheter for clinical purposes
  5. Able to consent in english

You CAN'T join if...

  1. Under 18 years of age
  2. unable to provide informed consent
  3. Pregnancy


  • University of California San Francisco
    San Francisco California 94122 United States

Lead Scientist at UCSF

  • Pekka Talke, MD
    Professor, Anesthesia, School of Medicine. Authored (or co-authored) 57 research publications


accepting new patients by invitation only
Start Date
Completion Date
University of California, San Francisco
Phase 1 Vascular Disease Research Study
Study Type
Expecting 40 study participants
Last Updated