Summary

for people ages 2-25 (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Philip Rosenthal

Description

Summary

Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: - Collect medical and other data to learn more about PSC, how it progresses, and identify factors that may cause the disease to progress more quickly. - Ask questions about how PSC symptoms affect your child's life to learn more about its impact on your child's daily functioning - Children with PSC who are seen at one of the participating clinical sites in the Childhood Liver Disease Research Network (ChiLDReN) will be asked to contribute information, DNA, and other specimens. The information and specimens will be available to investigators to carry out approved research aimed at learning more about the possible causes and long-term effects of PSC.

Official Title

Prospective Observational Study of Primary Sclerosing Cholangitis (PSC) in Children

Details

Pediatric primary sclerosing cholangitis (PSC) is a rare autoimmune biliary fibrosing disease that leads to significant morbidity, the need for liver transplantation in ~50% of patients, and an increased risk for biliary and colorectal cancers in adulthood. The progression of the biliary disease in children is variable and risk factors associated with a more rapid progression of disease have not been adequately studied. Importantly, pediatric hepatologists have never previously collaborated with inflammatory bowel disease (IBD) specialists to rigorously explore interactions between colonic inflammation and liver disease. New non-invasive imaging modalities to measure fibrosis have not been explored in pediatric PSC. Furthermore, the impact that PSC has on the global functioning of children is not well understood, and likely underappreciated.

The natural history of pediatric PSC is poorly understood. This study aims to determine risk factors, including activity of co-existent IBD, associated with more rapid progression of disease, characterize the impact of PSC on global functioning, define the spectrum and prognostic value of biliary tract disease and liver fibrosis based on novel imaging techniques, and establish a biobank of specimens for future mechanistic studies aimed at discovering biomarkers pertaining to etiology and severity of PSC and novel mechanisms of immunopathogenesis of disease. This comprehensive observational and longitudinal study will delineate unique aspects of the natural history and severity of pediatric PSC and of associated IBD and provide necessary data for future therapeutic trials. It aims to provide a platform to discover and validate circulating and imaging biomarkers, which may serve as surrogate endpoints in future interventional studies.

Keywords

Primary Sclerosing Cholangitis Liver Diseases Cholangitis, Sclerosing Pediatric Liver Disease Cholangitis

Eligibility

You can join if…

Open to people ages 2-25

Patients with the clinical diagnosis of large or small duct PSC made at any time prior to enrollment are screened for eligibility to participate in this prospective cohort study. The site PI will determine eligibility following review of MRCP or ERCP images with the site radiologist to confirm presence of an abnormal cholangiogram at the time of diagnosis of large duct PSC. Liver histopathology obtained at the time of diagnosis of small duct PSC will be reviewed with the site pathologist prior to enrollment.

Individuals must meet all of the Inclusion criteria in order to be eligible to participate in the study:

  1. Aged 2 through 25 years at time of screening.
  2. Diagnosis of large duct PSC based on review of cholangiogram by MRC, ERC, or intraoperative cholangiogram (IOC) by the site radiologist and interpreted to be consistent with PSC, based on one or more of the following:
  3. Focal structuring of the bile duct(s)
  4. Dominant stricture of the common bile duct
  5. Saccular dilatation of bile duct(s)
  6. Beaded appearance of bile duct(s)
  7. Pruning appearance of the distal bile duct branches

AND/OR

  1. Diagnosis of small duct PSC based on review of liver histopathology by the site pathologist and interpreted to be compatible with PSC:
  2. Probable small duct PSC: biopsy with ≥3 of 5 criteria: periductal edema, concentric inflammation, bile duct injury, ductular reaction, and neutrophils in bile ducts (cholangitis) OR...
  3. Definitive small duct PSC: Periductal fibrosis/ "onion skinning" around interlobular bile ducts or smaller profiles
  4. Stated willingness to comply with all study procedures and availability for the duration of the study.
  5. Able to provide informed consent/assent

You CAN'T join if...

An individual who meets any of the following criteria at baseline will be excluded from participation in this study.

  1. History of liver transplantation
  2. History bone marrow transplantation
  3. History of primary or acquired immunodeficiency predisposing to secondary sclerosing cholangitis, for instance: hyper-IgM syndrome, severe combined immunodeficiency (SCID) syndrome, common variable immunodeficiency (CVID) syndrome, cartilage hair hypoplasia syndrome, or HIV/AIDS
  4. History of histiocytosis, including Langerhans cell histiocytosis (LCH), or hemophagocytic lymphohistiocytosis (HLH)
  5. History of ischemic cholangitis
  6. History of portal vein thrombosis with biliopathy, veno-occlusive disease, or abdominal radiation vasculopathy
  7. History of recurrent pyogenic cholangitis
  8. History of biliary tract surgery for cholecystolithiasis prior to cholangiogram/liver biopsy evaluated to determine enrollment
  9. History of biliary tract surgery for choledochal cyst
  10. . History of hepatocellular carcinoma, or hepatoblastoma
  11. . History of surgical biliary trauma
  12. . History of congenital cytomegalovirus (CMV) hepatitis
  13. . History of Sickle Cell Disease
  14. . History of cystic fibrosis, biliary atresia, Caroli disease/congenital hepatic fibrosis, or progressive familial intrahepatic cholestasis type 3/MDR3 disease
  15. . History of cardiac hepatopathy.
  16. . History of metabolic disorders, including Wilson's disease, glycogen storage disorder, Alpha-1 Antitrypsin deficiency
  17. . Diagnosis of systemic lupus erythematosus (SLE)
  18. . Concurrent pregnancy at the time of enrollment -

Locations

  • University of California at San Francisco (UCSF) not yet accepting patients
    San Francisco California 94143 United States
  • Children's Hospital of Los Angeles not yet accepting patients
    Los Angeles California 90027 United States

Lead Scientist

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
Arbor Research Collaborative for Health
Links
Childhood Liver Disease Research Network (ChiLDReN) website
ID
NCT04181138
Study Type
Observational
Last Updated