for people ages 40-89 (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion
Principal Investigator
by Lea T Grinberg, MD, PhD
Photo of Lea T Grinberg
Lea T Grinberg



This study aims to discover whether acquiring basic-literacy in adulthood can improve episodic memory and brain structural and functional connectivity. In a collaborative project between Brazil and USA, the investigators will use a randomized controlled trial approach to leverage the level of evidence of the benefits of basic adult-education as a possible cognitive reserve builder. If successful, the study's findings will be important in shaping policies targeting increasing access to late-life education to reduce dementia risk.


Memory Impairment Literacy training Non-Literacy training


You can join if…

Open to people ages 40-89

Being illiterate (TOFHLA score <53) and availability to participate in the study for at least 12 months

You CAN'T join if...

A) Presence of remarkable cognitive complains and/or decompensated psychiatric illness (depression and anxiety) and/or current substance abuse such as alcohol and illicit drugs use.

B) Objective cognitive impairment: score of 2 standard deviations or bellow for age and education on the Mini-Mental State Evaluation (MMSE) and/or score of 6 or lower on the delayed recall task from the Brief Cognitive Battery.

C) History of previously diagnosed dyslexia D) Formal MRI contraindications including metal or claustrophobia. E) Severe structural lesions detected by MRI.

Lead Scientist at UCSF

  • Lea T Grinberg, MD, PhD
    Dr. Grinberg is a neuropathologist specializing in brain aging and associated disorders. She received her medical and doctorate degrees in São Paulo, Brazil. In 2003, Dr. Grinberg, along with colleagues from several disciplines founded a brain bank in São Paulo, Brazil, which has developed into an extremely prolific and highly regarded institution.


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated