for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion
Principal Investigator
by Christine Miaskowski, RN, PhD
Headshot of Christine Miaskowski
Christine Miaskowski



This clinical trial investigates if certain electronic games may be effective in improving attention and memory function in cancer survivors. Cancer related cognitive impairment (CRCI) is an issue experienced by many cancer patients/survivors. CRCI includes perceived or objective problems with memory, executive function, and attention/concentration. CRCI has a negative impact on survivors' ability to work, carry out routine activities, and engage in social and family relationships. CRCI may result in significant distress and reduced quality of life. Certain electronic games may help improve attention and memory function in cancer survivors and reduce symptoms of CRCI.

Official Title

A Pilot Study of A Novel Cognitive Intervention for Cancer Survivors


PRIMARY OBJECTIVES: I. Determine the recruitment and retention rates for both arms of this study. II. Determine the effect size for changes in cognitive function (i.e., Test of Variables of Attention (TOVA) [i.e. attention], Adaptive Cognitive Evaluation (ACE) [i.e. working memory]) in the intervention group compared to the control group following the 4-week study. III. Evaluate adherence rates for and satisfaction with the interventions. IV. Evaluate for treatment-related adverse events (e.g., nausea, motion sickness). SECONDARY OBJECTIVE: I. To determine effect sizes for depression, fatigue, and sleep disturbance, by comparing changes in the intervention group to changes in the control group, following the 4-week study. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients play Endeavor over 25 minutes daily 5 days a week for 4 weeks. ARM II: Patients play Words! over 25 minutes daily 5 days a week for 4 weeks.


Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm Neoplasms Endeavor: Computer-Based Cognitive Stimulation Intervention Words!: Computer-Based Cognitive Stimulation Intervention


You can join if…

Open to people ages 18 years and up

  • Attention Function Index (AFI) score of < 7.5
  • Are able to read, write, and understand English
  • Ability to understand an electronic informed consent document, and the willingness to sign it
  • Have a Karnofsky performance status (KPS) score of >= 50
  • Have access to WiFi connection

You CAN'T join if...

  • Receiving active treatment for cancer recurrence
  • Have significant cognitive impairment
  • Have sensory or motor deficits that prevent them from doing the assessment and using the application


  • University of California San Francisco accepting new patients
    San Francisco California 94143 United States

Lead Scientist at UCSF


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated