for people ages 18-95 (full criteria)
at San Francisco, California
study started
estimated completion
Principal Investigator
by Maria Luisa Gorno Tempini



The investigators will test the feasibility of using transcranial direct current stimulation (tDCS) and speech therapy to treat participants with motor speech disorders caused by Frontotemporal Lobar Degeneration Pathology including nonfluent variant Primary Progressive Aphasia, Progressive Supranuclear Palsy, Corticobasal Syndrome, or behavioral variant Frontotemporal Dementia. The investigators will deliver transcranial direct current stimulation (tDCS) either in a clinic setting at the University of California San Francisco, or in patients' homes, via a consumer tDCS device and videoconferencing. Transcranial direct current stimulation (tDCS) is a neuromodulation technique that can enhance the benefits of speech therapy treatment. Participants will receive a dose of tDCS stimulation + speech therapy and a dose of sham tDCS + speech therapy in a randomized double blind crossover study performed either in the clinic or at home via videoconferencing. This study can be performed entirely remotely.


Nonfluent Aphasia, Progressive Primary Progressive Nonfluent Aphasia Primary Progressive Non Fluent Aphasia Progressive Supranuclear Palsy Corticobasal Degeneration Behavioral Variant of Frontotemporal Dementia Motor Speech Disorders Dysarthria Apraxia of Speech Aphasia Supranuclear Palsy, Progressive Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Communication Disorders Speech Disorders Aphasia, Broca Halo Neuroscience Neurostimulator


You can join if…

Open to people ages 18-95

  • Mini Mental Status Exam score > 10
  • diagnosis of nfvPPA via Gorno-Tempini 2011 criteria, or a diagnosis of FTLD syndrome including progressive supranuclear palsy, corticobasal syndrome or behavioral variant frontotemporal dementia PLUS a motor speech disorder (apraxia of speech and/or dysarthria)
  • able to give consent
  • right-handed
  • native English speaker
  • having a caregiver who is also able to sign and understand the caregiver's consent form.

You CAN'T join if...

History of:

  • stroke
  • TBI
  • brain cancer
  • seizures
  • craniotomy, skull surgery or fracture
  • metallic implant in head
  • pacemaker or cardioverter-defibrillator
  • pregnancy.


  • University of California, San Francisco
    San Francisco California 94158 United States

Lead Scientist at UCSF


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated