Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Francisco, California and other locations
Dates
study started
estimated completion

Description

Summary

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Official Title

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR): A Randomized Controlled Trial

Keywords

Appendicitis post-operative antibiotics Anti-Bacterial Agents Antibiotics, Antitubercular Restricted Duration of SOC Antibiotic Use Liberal Duration of SOC Antibiotic Use

Eligibility

You can join if…

Open to people ages 18 years and up

  • Age ≥ 18 years
  • Planned appendectomy (laparoscopic or open) for simple or complicated (perforated or gangrenous) appendicitis
  • Working telephone number or reliable method to contact patient after hospital discharge

You CAN'T join if...

  • Unable to consent
  • Pregnant Women
  • Prisoners
  • Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS
  • Heart failure
  • Allergy to bupivacaine
  • Unlikely to comply with treatment or follow-up
  • Inpatient consultation for appendicitis
  • Clinically suspected of sepsis based on Sepsis-3 definition
  • Current use of antibiotics for other indications
  • Uncontrolled hyperglycemia or Type 1 Diabetes
  • Surgeon preference
  • Patient preference
  • Research team unavailable

Locations

  • University of California san Francisco
    San Francisco California 94143 United States
  • Denver Health and Hospital Authority
    Denver Colorado 80204-4507 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Denver Health and Hospital Authority
ID
NCT05002829
Study Type
Interventional
Participants
Expecting 2275 study participants
Last Updated