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Macular Edema clinical trials at UCSF
4 in progress, 1 open to new patients

  • PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial

    open to eligible people ages 18 years and up

    To evaluate the relative efficacy of three commonly utilized regional corticosteroids for the regional treatment of uveitic macular edema: periocular triamcinolone acetonide; intravitreal triamcinolone acetonide; intravitreal dexamethasone implant. The primary efficacy measure will be percent change in central subfield thickness as measured by OCT at 8 weeks. Participants will continue in the study for 24 weeks in order to evaluate relative effects of the 3 treatment strategies on the duration of treatment effects, requirement for additional injections, and adverse effects.

    San Francisco, California and other locations

  • Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema

    Sorry, not yet accepting patients

    Currently, diabetic macular edema is treated is through injection of a medications such as off-label bevacizumab, which decreases the swelling in the retina. These injections are sometimes required monthly until the condition is controlled. Recently, there have been some new FDA approved treatments using laser that decrease the swelling. These approximately ten minute treatments do not require injections and don't cause permanent damage to the eye, and they may decrease the number of injections one needs to get to treat diabetic macular edema (DME). The purpose of this randomized clinical trial is to determine whether subvisible laser in combination with intravitreal bevacizumab is non-inferior compared to current standard of care (intravitreal bevacizumab alone) in achieving favorable outcomes for visual acuity, mean macular thickness, and patient quality of life, and has fewer needed intravitreal bevacizumab injections throughout the course of the 12 month study period.

    San Francisco, California

  • Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy Trial

    Sorry, not yet accepting patients

    The Macular Edema Ranibizumab v. Intravitreal anti-inflammatory Therapy (MERIT) Trial will compare the relative efficacy and safety of intravitreal methotrexate, intravitreal ranibizumab, and the intravitreal dexamethasone implant for the treatment of uveitic macular edema persisting after an intravitreal corticosteroid injection. MERIT is a parallel design (1:1:1), randomized comparative trial with an anniversary close-out at the 6 month clinic visit. The primary outcome is percent change in central subfield thickness from the baseline OCT measurement to the 12 week visit.

    San Francisco, California and other locations

  • Topical Treatment for Uveitic Macular Edema

    Sorry, not yet accepting patients

    Macular edema is a condition in which there is swelling in the macula, the part of the retina that gives you your best vision. This swelling can cause your vision to get bad. When it is diagnosed early and treated, you vision usually can be preserved. However, if the swelling goes untreated for several months, it can cause permanent vision loss. We think that the three eye drop regimens in this study, difluprednate, prednisolone acetate, or nepafenac plus prednisolone acetate, might be effective in treating uveitic macular edema. Patients who enter this study are being randomized to one of the three regimens and are being followed for 24 weeks.

    San Francisco, California