Clinical Trials Open to Healthy Volunteers
A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCSF offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCSF researchers make better comparisons to better understand the treatment of diseases.
Showing trials for
Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO19)
- study on Hypoxia
- open to healthy people ages 18-50
Accuracy of Ultrasound for Detecting Residual Fragments During RIRS
- study on Kidney Stones and Ultrasound Therapy
- open to healthy people ages 18 years and up
Allergic Disease Onset Prevention Study
- study on Atopic Dermatitis (Eczema) and Type 1 Hypersensitivity
- open to healthy people
Alzheimer's Disease Neuroimaging Initiative 4
- study on Mild Cognitive Impairment and Alzheimer's Disease
- open to healthy people ages 55-90
American Lung Association (ALA) Lung Health Cohort
- study on Lung Diseases
- open to healthy people ages 25-35
AMP SCZ® Observational Study: PREDICT-DPACC
- study on Clinical High Risk and Psychotic Disorders
- open to healthy people ages 12-30
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
- study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
- open to healthy people ages 18 years and up
Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis
- study on Endometriosis and Ovarian Hyperstimulation
- open to healthy females ages 18-42
Attachment and Biobehavioral Catch-up and Depression Treatment
- study on Depression and Child Behavior
- open to healthy females ages 2 years and up
Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
- study on Antimicrobial Resistance and Morality
- open to healthy people ages 1 month and up
Backpack Weight Impacts
- open to healthy people ages 18-65
Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors
- study on Astrocytoma and Glioblastoma
- open to healthy people ages 18-80
BLOOM: Boldly Living outdOOrs for Mental Health
- study on Anxiety and Anxiety Disorders
- open to healthy people ages 9-12
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
- study on Neurodegenerative Disease
- open to healthy people ages 18 years and up
The Brain Health Study: A Pragmatic, Patient-Centered Trial
- study on Dementia and Alzheimer's Disease
- open to healthy people ages 65 years and up
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
- study on Post-Traumatic Stress Disorder and Insomnia
- open to healthy people ages 18-75
Cellular Aging and Neurobiology of Depression Study
- study on Depression
- open to healthy people ages 21-60
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
- study on CADASIL and Dementia
- open to healthy people ages 18 years and up
CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment
- study on Cystic Fibrosis and Fibrosis
- open to healthy people ages 18-65
Childhood Cancer Survivor Study
- study on Cancer, General
- open to healthy people
Clinical and Biological Characteristics of Hidradenitis Suppurativa
- study on Hidradenitis Suppurativa
- open to healthy people ages 13 years and up
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
- study on Postoperative Delirium and Postoperative Pain
- open to healthy people ages 60 years and up
Collaborative Approach to Examining Adversity and Building Resilience Study
- study on Early Life Adversity and Caregivers
- open to healthy people ages 2 years and up
Collection of Blood for Multiple Collaborative Studies
- study on HIV/AIDS
- open to healthy people ages 18 years and up
Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas
- study on Osteoid Osteoma
- open to healthy people ages 8 years and up
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
- study on Acne
- open to healthy females ages 16-40
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
- study on HIV/AIDS and Sexually Transmitted Infections
- open to healthy people ages 15 years and up
Comparing the Effects of Psilocin and Psilocybin in Healthy Adults
- study on Psilocybin
- open to healthy people ages 25-50
Consent for Use of Stored Patient Specimens for Future Testing
- study on HIV/AIDS
- open to healthy people
Contingency Management for Smoking Cessation
- study on Smoking Cessation and Tobacco
- open to healthy people ages 18 years and up
Dermatologic Research Evaluation and Monitoring of Sleep in Moderate-to-Severe Psoriasis
- study on Psoriasis
- open to healthy people ages 18 years and up
Determining Normal Range for Free Light Chains in Serum Among Twins
- study on Multiple Myeloma
- open to healthy people ages 18-80
Dexamethasone in Total Knee Arthroplasty
- study on Knee Replacement
- open to healthy people ages 18 years and up
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer
- study on Breast Screening and Breast Cancer
- open to healthy females ages 45-74
Direct-to-patient Teledermatology and Computer-assisted Diagnosis
- study on Telehealth
- open to healthy people ages 18 years and up
Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health
- study on Cancer, General
- open to healthy people ages 18 years and up
Dopaminergic Mechanisms Underlying Human Social Behavior
- study on Decision Making and Executive Function
- open to healthy people ages 18-40
The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis
- study on Periodontitis
- open to healthy people ages 18-80
Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
- study on Premature Birth and Early Labor
- open to healthy females
Enhanced Stress Resilience Training for Critical Care Nurses
- study on Mental Health and Stress
- open to healthy people
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
- study on Huntington's Disease
- open to healthy people ages 18 years and up
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
- study on Procedural Pain and Procedural Anxiety
- open to healthy people ages 5-17
Examine the Effects of Mindfulness in Woman With a History of Child Adversity
- study on Mental Health and Stress
- open to healthy females ages 30-50
Excipient Effect on Drug Absorption in Humans
- study on Impact of Excipients on Drug Absorption
- open to healthy people ages 18-64
Expanding Fertility Care to Poor and Low Resourced Settings Study
- study on Infertility and Fertility Disorders
- open to healthy males ages 18-64
EyeConic: Qualification for Cone-Optogenetics
- study on Retinal Dystrophies
- open to healthy people
Family Mental Health Family Navigator Project (FMHN)
- study on Mental Health
- open to healthy people ages 6-17
First-in-human Evaluation of EAAT2 PET Tracer in Healthy and Alzheimer's Diseased Brain
- study on Alzheimer's Disease
- open to healthy people ages 40-75
Guselkumab Immunogenetics
- study on Psoriasis and Guttate Psoriasis
- open to healthy people ages 18 years and up
The Heart Rhythm Twins Study
- study on Premature Atrial Complex and Premature Ventricular Contractions
- open to healthy people ages 18 years and up
HIV Prevention Peer Navigation for Justice Involved Women
- study on HIV/AIDS and Social Stigma
- open to healthy females ages 18-49
Hypertension in Young Adults Trial
- study on High Blood Pressure
- open to healthy people ages 18-40
Identification and Validation of Biomarkers for Breast Cancer Resistance Protein (BCRP)
- study on Breast Cancer
- open to healthy people ages 18-64
Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors
- study on Quality of Life
- open to healthy people ages 5 years and up
Immune Spatial Features of Guselkumab Cutaneous Response
- study on Psoriasis
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
Inflammation, Diabetes, Ethnicity and Obesity Cohort
- study on Obesity and Diabetes
- open to healthy people ages 18-75
Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM
- study on Methamphetamines
- open to healthy males ages 18-70
Investigation of Pupillometry as Guide for Extubation Readiness in Anesthetized Children
- study on Anesthesia and Laryngospasm on Emergence
- open to healthy people ages 2-10
KIDney Injury in Times of COVID-19 (KIDCOV)
- study on COVID-19 and Acute Kidney Injury
- open to healthy people ages 18 years and up
LetSync: Pilot Test of Mobile Health (mHealth) Intervention
- study on HIV/AIDS and Immunodeficiency
- open to healthy males ages 18 years and up
Longitudinal Early-onset Alzheimer's Disease Study Protocol
- study on Alzheimer's Disease and Mild Cognitive Impairment
- open to healthy people ages 40-64
Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
- study on Sturge-Weber Syndrome
- open to healthy people
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
- study on Chronic Obstructive Pulmonary Disease and Smoking Cessation
- open to healthy people ages 40-75
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
- study on Schizophrenia
- open to healthy people ages 18-64
Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care
- study on Cancer, General and Hematopoietic and Lymphoid Cell Neoplasm
- open to healthy people
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
- study on Cannabis and Tobacco
- open to healthy people ages 18 years and up
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
- study on Depression
- open to healthy people ages 18 years and up
Neural and Physiological Correlates of Psychedelic Sub-states
- study on Psychedelic Experiences and Neuroimaging
- open to healthy people ages 21-70
Neurofilament Surveillance Project (NSP)
- study on Dementia and Frontotemporal Dementia
- open to healthy people ages 18-85
A Neuroimaging Study of Open-label Placebo in Depressed Adolescents
- study on Depression
- open to healthy people ages 13-18
Pancreatic Cancer Early Detection Consortium
- study on Pancreatic Cancer and Pancreas Cyst
- open to healthy people ages 18-90
Parenting Stress mHealth
- study on Mental Health and Stress
- open to healthy people ages 12 years and up
Parkinson Progression Marker Initiative Online (PPMI Online)
- study on Parkinson's Disease
- open to healthy people ages 18 years and up
PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)
- study on HIV/AIDS
- open to healthy people ages 18 years and up
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
- study on Nicotine and Tobacco
- open to healthy people ages 21-70
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens
- study on Risk Reduction and Breast Cancer
- open to healthy females ages 45-64
Physical Activity and Fertility Care Study
- study on Infertility
- open to healthy females ages 18-43
Pilot Study of Pancreatic Cancer Screening
- study on Pancreatic Cancer and Pancreatic Neoplasms
- open to healthy people ages 18 years and up
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
- study on Hernia
- open to healthy females ages 18 years and up
Post-Injury Platelet Biology: Mechanisms and Outcomes
- study on Wound and Injuries and Blood Platelets
- open to healthy people ages 18 years and up
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
- study on Parkinson's Disease
- open to healthy people ages 30 years and up
Pragmatic Trial of WHT vs. PC-GE to Promote Non-Pharmacological Strategies to Treat Chronic Pain in Veterans
- study on Pain
- open to healthy people ages 18 years and up
PrEP Affect Regulation Treatment Innovation
- study on Medication Adherence and HIV/AIDS
- open to healthy males ages 18 years and up
Progression and Etiology of Cortical Porosity in Diabetic Bone Disease
- study on Diabetes and Diabetes Type 2
- open to healthy people ages 50-70
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
- study on Opioid Toxicity and Pupillary Miosis
- open to healthy people ages 40-60
Reaching for Equity in Sleep Apnea Treatment (REST) Study
- study on Sleep Apnea and Sleep Disorders
- open to healthy people ages 18 years and up
Reducing Pesticide Exposures in Child Care Centers
- study on Risk Reduction and Environmental Exposure
- open to healthy people ages 3-75
The Resilience Clinic Evaluation
- study on Early Life Adversity and Caregivers
- open to healthy people ages 2-5
Retinal Imaging in Patients With Inherited Retinal Degenerations
- study on Retinitis Pigmentosa
- open to healthy people ages 13 years and up
A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid Eye Disease (TED)
- study on Thyroid Eye Disease and Nicotine
- open to healthy people ages 18 years and up
Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries
- study on Caries and Metabolomic Profile
- open to healthy people ages 5-10
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
- study on Cardiovascular Disease and Nicotine
- open to healthy people ages 21-70
A Silver Lining in the VAD Sky
- study on Driveline Infections
- open to healthy people ages 18 years and up
SKY Breath Intervention
- study on Depression and Anxiety
- open to healthy people ages 16-24
Sleep and Social Experiences Study 2
- study on Sleep and Blood Pressure
- open to healthy people ages 18-64
Smoke-free Home Intervention in Permanent Supportive Housing
- study on Smoking Cessation and Tobacco
- open to healthy people ages 18 years and up
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)
- study on Asthma
- open to healthy people ages 18-70
SPIROMICS Study of Early COPD Progression (SOURCE)
- study on Chronic Obstructive Pulmonary Disease
- open to healthy people ages 30-55
SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)
- study on Sphingolipidoses and Enzyme Deficiency
- open to healthy people
Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
- study on BRCA 1 Gene Mutation and Breast Cancer
- open to healthy females ages 25-55
THC Crossover Study
- study on THC and Cannabis
- open to healthy people ages 21 years and up
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
- study on Lower Back Pain and Pain
- open to healthy people ages 21-85
Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli
- study on Neurocognitive Dysfunction and Premature Ventricular Contractions
- open to healthy people ages 18 years and up
TReating Incontinence for Underlying Mental and Physical Health
- study on Urinary Incontinence and Overactive Bladder
- open to healthy females ages 60 years and up
Treatment for Speech and Language in Primary Progressive Aphasia
- study on Primary Progressive Aphasia and Dementia
- open to healthy people
TrialNet Pathway to Prevention of T1D
- study on Diabetes and Diabetes Type 1
- open to healthy people ages 30 months to 45 years
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
- study on COVID-19
- open to healthy people ages 18 years and up
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
- study on HIV/AIDS
- open to healthy people ages 18-70
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
- study on Pain and Knee Pain
- open to healthy people ages 18-75
The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings
- study on Perioperative Pain and Perioperative Anxiety
- open to healthy people ages 18-75
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
- study on Depression
- open to healthy people ages 18-65
Valacyclovir in Pain Management of Acute Apical Abscesses
- study on Acute Apical Abscess and Pain
- open to healthy people ages 18-80
Wayfinding Intervention and Long-Term Memory
- study on Long-Term Memory Decline and Mild Cognitive Impairment
- open to healthy people ages 60-85
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
- study on Breast Cancer
- open to healthy females ages 40-74