Clinical Trials Open to Healthy Volunteers
A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCSF offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCSF researchers make better comparisons to better understand the treatment of diseases.
Showing trials for
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
- study on Postoperative Delirium and Postoperative Pain
- open to healthy people ages 60 years and up
A Neuroimaging Study of Open-label Placebo in Depressed Adolescents
- study on Depression
- open to healthy people ages 13-18
A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid Eye Disease (TED)
- study on Thyroid Eye Disease
- open to healthy people ages 18 years and up
A Silver Lining in the VAD Sky
- study on Driveline Infections
- open to healthy people ages 18 years and up
Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO19)
- study on Hypoxia
- open to healthy people ages 18-50
Accuracy of Ultrasound for Detecting Residual Fragments During RIRS
- study on Kidney Stones and Ultrasound Therapy
- open to healthy people ages 18 years and up
Addressing Heavy Alcohol Use Consumption With Kudzu
- study on Alcohol Use and Sexually Transmitted Infections
- open to healthy people ages 18-70
Allergic Disease Onset Prevention Study
- study on Atopic Dermatitis (Eczema) and Type 1 Hypersensitivity
- open to healthy people
Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol
- study on Mild Cognitive Impairment and Alzheimer's Disease
- open to healthy people ages 55-90
American Lung Association (ALA) Lung Health Cohort
- study on Lung Diseases
- open to healthy people ages 25-35
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
- study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
- open to healthy people ages 18 years and up
Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis
- study on Endometriosis and Ovarian Hyperstimulation
- open to healthy females ages 18-42
Attachment and Biobehavioral Catch-up and Depression Treatment
- study on Depression and Child Behavior
- open to healthy females ages 2 years and up
Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
- study on Antimicrobial Resistance and Morality
- open to healthy people ages 1 month and up
Backpack Weight Impacts
- open to healthy people ages 18-65
Black Economic Equity Movement
- study on Mental Health and Health Care Utilization
- open to healthy people ages 18-24
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
- study on Neurodegenerative Disease
- open to healthy people ages 18 years and up
Cellular Aging and Neurobiology of Depression Study
- study on Depression
- open to healthy people ages 21-60
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
- study on CADASIL and Dementia
- open to healthy people ages 18 years and up
CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment
- study on Cystic Fibrosis and Fibrosis
- open to healthy people ages 18-65
Childhood Cancer Survivor Study
- study on Cancer, General
- open to healthy people
Clinical and Biological Characteristics of Hidradenitis Suppurativa
- study on Hidradenitis Suppurativa
- open to healthy people ages 13 years and up
Collaborative Approach to Examining Adversity and Building Resilience Study
- study on Early Life Adversity and Caregivers
- open to healthy people ages 2 years and up
Collection of Blood for Multiple Collaborative Studies
- study on HIV/AIDS
- open to healthy people ages 18 years and up
Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas
- study on Osteoid Osteoma
- open to healthy people ages 8 years and up
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
- study on Acne
- open to healthy females ages 16-40
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
- study on HIV/AIDS and Sexually Transmitted Infections
- open to healthy people ages 15 years and up
Comparing the Effects of Psilocin and Psilocybin in Healthy Adults
- study on Psilocybin
- open to healthy people ages 25-50
Consent for Use of Stored Patient Specimens for Future Testing
- study on HIV/AIDS
- open to healthy people
Contingency Management for Smoking Cessation
- study on Smoking Cessation and Tobacco
- open to healthy people ages 18 years and up
Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke
- study on Smoke Inhalation and Exposure to Pollution
- open to healthy people ages 18-50
Dermatologic Research Evaluation and Monitoring of Sleep in Moderate-to-Severe Psoriasis
- study on Psoriasis
- open to healthy people ages 18 years and up
Determining Normal Range for Free Light Chains in Serum Among Twins
- study on Multiple Myeloma
- open to healthy people ages 18-80
Dexamethasone in Total Knee Arthroplasty
- study on Knee Replacement
- open to healthy people ages 18 years and up
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer
- study on Breast Screening and Breast Cancer
- open to healthy females ages 45-74
Direct-to-patient Teledermatology and Computer-assisted Diagnosis
- study on Telehealth
- open to healthy people ages 18 years and up
Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health
- study on Cancer, General
- open to healthy people ages 18 years and up
Dopaminergic Mechanisms Underlying Human Social Behavior
- study on Decision Making and Executive Function
- open to healthy people ages 18-40
Effects of Nutritional Preconditioning on the Patient's Outcomes After Surgery
- study on Major Abdominal/GI Surgery
- open to healthy people ages 18 years and up
Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
- study on Premature Birth and Early Labor
- open to healthy females
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
- study on Huntington's Disease
- open to healthy people ages 18 years and up
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
- study on Procedural Pain and Procedural Anxiety
- open to healthy people ages 5-17
Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry
- study on Kidney Transplant and Transplants
- open to healthy people ages 18 years and up
Examine the Effects of Mindfulness in Woman With a History of Child Adversity
- study on Mental Health and Stress
- open to healthy females ages 30-50
Excipient Effect on Drug Absorption in Humans
- study on Impact of Excipients on Drug Absorption
- open to healthy people ages 18-64
Expanding Fertility Care to Poor and Low Resourced Settings Study
- study on Infertility and Fertility Disorders
- open to healthy males ages 18-64
EyeConic: Qualification for Cone-Optogenetics
- study on Retinal Dystrophies
- open to healthy people
Family Mental Health Family Navigator Project (FMHN)
- study on Mental Health
- open to healthy people ages 6-17
First-in-human Evaluation of EAAT2 PET Tracer in Healthy and Alzheimer's Diseased Brain
- study on Alzheimer's Disease
- open to healthy people ages 40-75
Guselkumab Immunogenetics
- study on Psoriasis and Guttate Psoriasis
- open to healthy people ages 18 years and up
The Heart Rhythm Twins Study
- study on Premature Atrial Complex and Premature Ventricular Contractions
- open to healthy people ages 18 years and up
HIV Prevention Peer Navigation for Justice Involved Women
- study on HIV/AIDS and Social Stigma
- open to healthy females ages 18-49
Hypertension in Young Adults Trial
- study on High Blood Pressure
- open to healthy people ages 18-35
Identification and Validation of Biomarkers for Breast Cancer Resistance Protein (BCRP)
- study on Breast Cancer
- open to healthy people ages 18-64
Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors
- study on Quality of Life
- open to healthy people ages 5 years and up
Immune Spatial Features of Guselkumab Cutaneous Response
- study on Psoriasis
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables
- study on Dementia and Mild Cognitive Impairment
- open to healthy people ages 18 years and up
Inflammation, Diabetes, Ethnicity and Obesity Cohort
- study on Obesity and Diabetes
- open to healthy people ages 18-75
Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM
- study on Methamphetamines
- open to healthy males ages 18-70
Investigation of Pupillometry as Guide for Extubation Readiness in Anesthetized Children
- study on Anesthesia and Laryngospasm on Emergence
- open to healthy people ages 2-10
KIDney Injury in Times of COVID-19 (KIDCOV)
- study on COVID-19 and Acute Kidney Injury
- open to healthy people ages 18 years and up
LetSync: Pilot Test of Mobile Health (mHealth) Intervention
- study on HIV/AIDS and Immunodeficiency
- open to healthy males ages 18 years and up
Longitudinal Early-onset Alzheimer's Disease Study Protocol
- study on Alzheimer's Disease and Mild Cognitive Impairment
- open to healthy people ages 40-64
Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
- study on Sturge-Weber Syndrome
- open to healthy people
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
- study on Chronic Obstructive Pulmonary Disease and Smoking Cessation
- open to healthy people ages 40-75
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
- study on Schizophrenia
- open to healthy people ages 18-64
Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care
- study on Cancer, General and Hematopoietic and Lymphoid Cell Neoplasm
- open to healthy people
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
- study on Cannabis and Tobacco
- open to healthy people ages 18 years and up
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
- study on Depression
- open to healthy people ages 18 years and up
Neurofilament Surveillance Project (NSP)
- study on Dementia and Frontotemporal Dementia
- open to healthy people ages 18-85
Optimizing Mindfulness Based Cognitive Therapy (MBCT) Maintenance
- study on Depression
- open to healthy people ages 18 years and up
Pancreatic Cancer Early Detection Consortium
- study on Pancreatic Cancer and Pancreas Cyst
- open to healthy people ages 18-90
Parenting Stress mHealth
- study on Mental Health and Stress
- open to healthy people ages 12 years and up
Parkinson Progression Marker Initiative Online (PPMI Online)
- study on Parkinson's Disease
- open to healthy people ages 18 years and up
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
- study on Nicotine and Tobacco
- open to healthy people ages 21-70
Physical Activity and Fertility Care Study
- study on Infertility
- open to healthy females ages 18-43
Pilot Study of Pancreatic Cancer Screening
- study on Pancreatic Cancer and Pancreatic Neoplasms
- open to healthy people ages 18 years and up
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
- study on Hernia
- open to healthy females ages 18 years and up
Post-Injury Platelet Biology: Mechanisms and Outcomes
- study on Wound and Injuries and Blood Platelets
- open to healthy people ages 18 years and up
PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort
- study on Parkinson's Disease
- open to healthy people ages 30 years and up
Pragmatic Trial of WHT vs. PC-GE to Promote Non-Pharmacological Strategies to Treat Chronic Pain in Veterans
- study on Pain
- open to healthy people ages 18 years and up
PrEP Affect Regulation Treatment Innovation
- study on Medication Adherence and HIV/AIDS
- open to healthy males ages 18 years and up
Progression and Etiology of Cortical Porosity in Diabetic Bone Disease
- study on Diabetes and Diabetes Type 2
- open to healthy people ages 50-70
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
- study on Opioid Toxicity and Pupillary Miosis
- open to healthy people ages 40-60
Reaching for Equity in Sleep Apnea Treatment (REST) Study
- study on Sleep Apnea and Sleep Disorders
- open to healthy people ages 18 years and up
Reducing Pesticide Exposures in Child Care Centers
- study on Risk Reduction and Environmental Exposure
- open to healthy people ages 3-75
Retinal Imaging in Patients With Inherited Retinal Degenerations
- study on Retinitis Pigmentosa
- open to healthy people ages 13 years and up
Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries
- study on Caries and Metabolomic Profile
- open to healthy people ages 5-10
Severe Asthma Research Program
- study on Asthma
- open to healthy people ages 6 years and up
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
- study on Cardiovascular Disease and Nicotine
- open to healthy people ages 21-70
SKY Breath Intervention
- study on Depression and Anxiety Disorders
- open to healthy people ages 16-24
Sleep and Social Experiences Study 2
- study on Sleep and Blood Pressure
- open to healthy people ages 18-64
Smoke-free Home Intervention in Permanent Supportive Housing
- study on Smoking Cessation and Tobacco
- open to healthy people ages 18 years and up
Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents
- study on Vaping and Cannabis
- open to healthy people ages 13-21
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)
- study on Asthma
- open to healthy people ages 18-70
SPIROMICS Study of Early COPD Progression (SOURCE)
- study on Chronic Obstructive Pulmonary Disease
- open to healthy people ages 30-55
SPL Insufficiency Syndrome (SPLIS): a SPLIS Observational Study and Patient Registry (International)
- study on Sphingolipidoses and Enzyme Deficiency
- open to healthy people
Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
- study on BRCA 1 Gene Mutation and Breast Cancer
- open to healthy females ages 25-55
THC Crossover Study
- study on THC and Cannabis
- open to healthy people ages 21 years and up
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
- study on Lower Back Pain and Pain
- open to healthy people ages 21-85
Translating Anesthesia Care Throughout
- study on Limited English Proficiency and Perioperative Care
- open to healthy people ages 18 years and up
Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli
- study on Neurocognitive Dysfunction and Premature Ventricular Contractions
- open to healthy people ages 18 years and up
TReating Incontinence for Underlying Mental and Physical Health
- study on Urinary Incontinence and Overactive Bladder
- open to healthy females ages 60 years and up
Treatment for Speech and Language in Primary Progressive Aphasia
- study on Primary Progressive Aphasia and Dementia
- open to healthy people
TrialNet Pathway to Prevention of T1D
- study on Diabetes and Diabetes Type 1
- open to healthy people ages 30 months to 45 years
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
- study on COVID-19
- open to healthy people ages 18 years and up
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
- study on HIV/AIDS
- open to healthy people ages 18-70
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
- study on Pain and Knee Pain
- open to healthy people ages 18-75
The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings
- study on Perioperative Pain and Perioperative Anxiety
- open to healthy people ages 18-75
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
- study on Depression
- open to healthy people ages 18-65
Wayfinding Intervention and Long-Term Memory
- study on Long-Term Memory Decline and Mild Cognitive Impairment
- open to healthy people ages 60-85
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
- study on Breast Cancer
- open to healthy females ages 40-74