Clinical Trials Open to Healthy Volunteers

A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCSF offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCSF researchers make better comparisons to better understand the treatment of diseases.

• A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain

  • study on Postoperative Delirium and Postoperative Pain
  • open to healthy people ages 60 years and up

• A Neuroimaging Study of Open-label Placebo in Depressed Adolescents

  • study on Depression
  • open to healthy people ages 13-18

• A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid Eye Disease (TED)

  • study on Thyroid Eye Disease
  • open to healthy people ages 18 years and up

• A Silver Lining in the VAD Sky

  • study on Driveline Infections
  • open to healthy people ages 18 years and up

• Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO19)

  • study on Hypoxia
  • open to healthy people ages 18-50

• Accuracy of Ultrasound for Detecting Residual Fragments During RIRS

  • study on Kidney Stones and Ultrasound Therapy
  • open to healthy people ages 18 years and up

• Addressing Heavy Alcohol Use Consumption With Kudzu

  • study on Alcohol Use and Sexually Transmitted Infections
  • open to healthy people ages 18-70

• Allergic Disease Onset Prevention Study

  • study on Atopic Dermatitis (Eczema) and Type 1 Hypersensitivity
  • open to healthy people

• Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 55-90

• American Lung Association (ALA) Lung Health Cohort

  • study on Lung Diseases
  • open to healthy people ages 25-35

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
  • open to healthy people ages 18 years and up

• Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis

  • study on Endometriosis and Ovarian Hyperstimulation
  • open to healthy females ages 18-42

• Attachment and Biobehavioral Catch-up and Depression Treatment

  • study on Depression and Child Behavior
  • open to healthy females ages 2 years and up

• Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)

  • study on Antimicrobial Resistance and Morality
  • open to healthy people ages 1 month and up

• Backpack Weight Impacts

  • open to healthy people ages 18-65

• Black Economic Equity Movement

  • study on Mental Health and Health Care Utilization
  • open to healthy people ages 18-24

• Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research

  • study on Neurodegenerative Disease
  • open to healthy people ages 18 years and up

• Cellular Aging and Neurobiology of Depression Study

  • study on Depression
  • open to healthy people ages 21-60

• Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

  • study on CADASIL and Dementia
  • open to healthy people ages 18 years and up

• CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment

  • study on Cystic Fibrosis and Fibrosis
  • open to healthy people ages 18-65

• Childhood Cancer Survivor Study

  • study on Cancer, General
  • open to healthy people

• Clinical and Biological Characteristics of Hidradenitis Suppurativa

  • study on Hidradenitis Suppurativa
  • open to healthy people ages 13 years and up

• Collaborative Approach to Examining Adversity and Building Resilience Study

  • study on Early Life Adversity and Caregivers
  • open to healthy people ages 2 years and up

• Collection of Blood for Multiple Collaborative Studies

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas

  • study on Osteoid Osteoma
  • open to healthy people ages 8 years and up

• Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne

  • study on Acne
  • open to healthy females ages 16-40

• Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention

  • study on HIV/AIDS and Sexually Transmitted Infections
  • open to healthy people ages 15 years and up

• Comparing the Effects of Psilocin and Psilocybin in Healthy Adults

  • study on Psilocybin
  • open to healthy people ages 25-50

• Consent for Use of Stored Patient Specimens for Future Testing

  • study on HIV/AIDS
  • open to healthy people

• Contingency Management for Smoking Cessation

  • study on Smoking Cessation and Tobacco
  • open to healthy people ages 18 years and up

• Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke

  • study on Smoke Inhalation and Exposure to Pollution
  • open to healthy people ages 18-50

• Dermatologic Research Evaluation and Monitoring of Sleep in Moderate-to-Severe Psoriasis

  • study on Psoriasis
  • open to healthy people ages 18 years and up

• Determining Normal Range for Free Light Chains in Serum Among Twins

  • study on Multiple Myeloma
  • open to healthy people ages 18-80

• Dexamethasone in Total Knee Arthroplasty

  • study on Knee Replacement
  • open to healthy people ages 18 years and up

• Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

  • study on Breast Screening and Breast Cancer
  • open to healthy females ages 45-74

• Direct-to-patient Teledermatology and Computer-assisted Diagnosis

  • study on Telehealth
  • open to healthy people ages 18 years and up

• Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health

  • study on Cancer, General
  • open to healthy people ages 18 years and up

• Dopaminergic Mechanisms Underlying Human Social Behavior

  • study on Decision Making and Executive Function
  • open to healthy people ages 18-40

• Effects of Nutritional Preconditioning on the Patient's Outcomes After Surgery

  • study on Major Abdominal/GI Surgery
  • open to healthy people ages 18 years and up

• Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

  • study on Premature Birth and Early Labor
  • open to healthy females

• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• Evaluating the Feasibility of VR for Pediatric Renal Biopsies

  • study on Procedural Pain and Procedural Anxiety
  • open to healthy people ages 5-17

• Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

  • study on Kidney Transplant and Transplants
  • open to healthy people ages 18 years and up

• Examine the Effects of Mindfulness in Woman With a History of Child Adversity

  • study on Mental Health and Stress
  • open to healthy females ages 30-50

• Excipient Effect on Drug Absorption in Humans

  • study on Impact of Excipients on Drug Absorption
  • open to healthy people ages 18-64

• Expanding Fertility Care to Poor and Low Resourced Settings Study

  • study on Infertility and Fertility Disorders
  • open to healthy males ages 18-64

• EyeConic: Qualification for Cone-Optogenetics

  • study on Retinal Dystrophies
  • open to healthy people

• Family Mental Health Family Navigator Project (FMHN)

  • study on Mental Health
  • open to healthy people ages 6-17

• First-in-human Evaluation of EAAT2 PET Tracer in Healthy and Alzheimer's Diseased Brain

  • study on Alzheimer's Disease
  • open to healthy people ages 40-75

• Guselkumab Immunogenetics

  • study on Psoriasis and Guttate Psoriasis
  • open to healthy people ages 18 years and up

• The Heart Rhythm Twins Study

  • study on Premature Atrial Complex and Premature Ventricular Contractions
  • open to healthy people ages 18 years and up

• HIV Prevention Peer Navigation for Justice Involved Women

  • study on HIV/AIDS and Social Stigma
  • open to healthy females ages 18-49

• Hypertension in Young Adults Trial

  • study on High Blood Pressure
  • open to healthy people ages 18-35

• Identification and Validation of Biomarkers for Breast Cancer Resistance Protein (BCRP)

  • study on Breast Cancer
  • open to healthy people ages 18-64

• Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors

  • study on Quality of Life
  • open to healthy people ages 5 years and up

• Immune Spatial Features of Guselkumab Cutaneous Response

  • study on Psoriasis
  • open to healthy people ages 18 years and up

• In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes

  • study on Dementia and Mild Cognitive Impairment
  • open to healthy people ages 18 years and up

• In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes

  • study on Dementia and Mild Cognitive Impairment
  • open to healthy people ages 18 years and up

• In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables

  • study on Dementia and Mild Cognitive Impairment
  • open to healthy people ages 18 years and up

• Inflammation, Diabetes, Ethnicity and Obesity Cohort

  • study on Obesity and Diabetes
  • open to healthy people ages 18-75

• Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM

  • study on Methamphetamines
  • open to healthy males ages 18-70

• Investigation of Pupillometry as Guide for Extubation Readiness in Anesthetized Children

  • study on Anesthesia and Laryngospasm on Emergence
  • open to healthy people ages 2-10

• KIDney Injury in Times of COVID-19 (KIDCOV)

  • study on COVID-19 and Acute Kidney Injury
  • open to healthy people ages 18 years and up

• LetSync: Pilot Test of Mobile Health (mHealth) Intervention

  • study on HIV/AIDS and Immunodeficiency
  • open to healthy males ages 18 years and up

• Longitudinal Early-onset Alzheimer's Disease Study Protocol

  • study on Alzheimer's Disease and Mild Cognitive Impairment
  • open to healthy people ages 40-64

• Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome

  • study on Sturge-Weber Syndrome
  • open to healthy people

• Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

  • study on Chronic Obstructive Pulmonary Disease and Smoking Cessation
  • open to healthy people ages 40-75

• Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

  • study on Schizophrenia
  • open to healthy people ages 18-64

• Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care

  • study on Cancer, General and Hematopoietic and Lymphoid Cell Neoplasm
  • open to healthy people

• N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use

  • study on Cannabis and Tobacco
  • open to healthy people ages 18 years and up

• Near Infrared Spectroscopy (NIRS) for Assessment of Depression

  • study on Depression
  • open to healthy people ages 18 years and up

• Neurofilament Surveillance Project (NSP)

  • study on Dementia and Frontotemporal Dementia
  • open to healthy people ages 18-85

• Optimizing Mindfulness Based Cognitive Therapy (MBCT) Maintenance

  • study on Depression
  • open to healthy people ages 18 years and up

• Pancreatic Cancer Early Detection Consortium

  • study on Pancreatic Cancer and Pancreas Cyst
  • open to healthy people ages 18-90

• Parenting Stress mHealth

  • study on Mental Health and Stress
  • open to healthy people ages 12 years and up

• Parkinson Progression Marker Initiative Online (PPMI Online)

  • study on Parkinson's Disease
  • open to healthy people ages 18 years and up

• Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

  • study on Nicotine and Tobacco
  • open to healthy people ages 21-70

• Physical Activity and Fertility Care Study

  • study on Infertility
  • open to healthy females ages 18-43

• Pilot Study of Pancreatic Cancer Screening

  • study on Pancreatic Cancer and Pancreatic Neoplasms
  • open to healthy people ages 18 years and up

• Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)

  • study on Hernia
  • open to healthy females ages 18 years and up

• Post-Injury Platelet Biology: Mechanisms and Outcomes

  • study on Wound and Injuries and Blood Platelets
  • open to healthy people ages 18 years and up

• PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort

  • study on Parkinson's Disease
  • open to healthy people ages 30 years and up

• Pragmatic Trial of WHT vs. PC-GE to Promote Non-Pharmacological Strategies to Treat Chronic Pain in Veterans

  • study on Pain
  • open to healthy people ages 18 years and up

• PrEP Affect Regulation Treatment Innovation

  • study on Medication Adherence and HIV/AIDS
  • open to healthy males ages 18 years and up

• Progression and Etiology of Cortical Porosity in Diabetic Bone Disease

  • study on Diabetes and Diabetes Type 2
  • open to healthy people ages 50-70

• Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

  • study on Opioid Toxicity and Pupillary Miosis
  • open to healthy people ages 40-60

• Reaching for Equity in Sleep Apnea Treatment (REST) Study

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 18 years and up

• Reducing Pesticide Exposures in Child Care Centers

  • study on Risk Reduction and Environmental Exposure
  • open to healthy people ages 3-75

• Retinal Imaging in Patients With Inherited Retinal Degenerations

  • study on Retinitis Pigmentosa
  • open to healthy people ages 13 years and up

• Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries

  • study on Caries and Metabolomic Profile
  • open to healthy people ages 5-10

• Severe Asthma Research Program

  • study on Asthma
  • open to healthy people ages 6 years and up

• Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

  • study on Cardiovascular Disease and Nicotine
  • open to healthy people ages 21-70

• SKY Breath Intervention

  • study on Depression and Anxiety Disorders
  • open to healthy people ages 16-24

• Sleep and Social Experiences Study 2

  • study on Sleep and Blood Pressure
  • open to healthy people ages 18-64

• Smoke-free Home Intervention in Permanent Supportive Housing

  • study on Smoking Cessation and Tobacco
  • open to healthy people ages 18 years and up

• Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

  • study on Vaping and Cannabis
  • open to healthy people ages 13-21

• Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)

  • study on Asthma
  • open to healthy people ages 18-70

• SPIROMICS Study of Early COPD Progression (SOURCE)

  • study on Chronic Obstructive Pulmonary Disease
  • open to healthy people ages 30-55

• SPL Insufficiency Syndrome (SPLIS): a SPLIS Observational Study and Patient Registry (International)

  • study on Sphingolipidoses and Enzyme Deficiency
  • open to healthy people

• Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation

  • study on BRCA 1 Gene Mutation and Breast Cancer
  • open to healthy females ages 25-55

• THC Crossover Study

  • study on THC and Cannabis
  • open to healthy people ages 21 years and up

• Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain

  • study on Lower Back Pain and Pain
  • open to healthy people ages 21-85

• Translating Anesthesia Care Throughout

  • study on Limited English Proficiency and Perioperative Care
  • open to healthy people ages 18 years and up

• Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli

  • study on Neurocognitive Dysfunction and Premature Ventricular Contractions
  • open to healthy people ages 18 years and up

• TReating Incontinence for Underlying Mental and Physical Health

  • study on Urinary Incontinence and Overactive Bladder
  • open to healthy females ages 60 years and up

• Treatment for Speech and Language in Primary Progressive Aphasia

  • study on Primary Progressive Aphasia and Dementia
  • open to healthy people

• TrialNet Pathway to Prevention of T1D

  • study on Diabetes and Diabetes Type 1
  • open to healthy people ages 30 months to 45 years

• Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)

  • study on COVID-19
  • open to healthy people ages 18 years and up

• The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

  • study on HIV/AIDS
  • open to healthy people ages 18-70

• The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement

  • study on Pain and Knee Pain
  • open to healthy people ages 18-75

• The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings

  • study on Perioperative Pain and Perioperative Anxiety
  • open to healthy people ages 18-75

• Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

  • study on Depression
  • open to healthy people ages 18-65

• Wayfinding Intervention and Long-Term Memory

  • study on Long-Term Memory Decline and Mild Cognitive Impairment
  • open to healthy people ages 60-85

• Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

  • study on Breast Cancer
  • open to healthy females ages 40-74