Clinical Trials Open to Healthy Volunteers

A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCSF offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCSF researchers make better comparisons to better understand the treatment of diseases.

• Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation

  • study on Mild Cognitive Impairment and Meditation
  • open to healthy people ages 60-85

• Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia

  • study on Hypoxia
  • open to healthy people ages 18-49

• Advance Care Planning With Formerly Homeless Older Adults Residing in Permanent Supportive Housing

  • study on End of Life
  • open to healthy people ages 50 years and up

• Alzheimer's Disease Neuroimaging Initiative 4

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 55-90

• American Lung Association (ALA) Lung Health Cohort

  • study on Lung Diseases
  • open to healthy people ages 25-35

• AMP SCZ® Observational Study: PREDICT-DPACC

  • study on Psychotic Disorders and Schizophrenia
  • open to healthy people ages 12-30

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
  • open to healthy people ages 18 years and up

• ASSESS ALL ALS Study

  • study on Amyotropic Lateral Sclerosis (ALS) and Acute Lymphoblastic Leukemia
  • open to healthy people ages 18 years and up

• Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

  • study on Obstetric Complication and Labor and Delivery Complication
  • open to healthy females

• Bazedoxifene Plus Conjugated Estrogens

  • study on Breast Cancer and Menopause
  • open to healthy females ages 45-64

• Biological and Behavioral Outcomes of Community Nature Walks

  • study on Mental Health and Stress
  • open to healthy people ages 18 years and up

• BLOOM: Boldly Living outdOOrs for Mental Health

  • study on Anxiety and Post-Traumatic Stress Disorder
  • open to healthy people ages 9-12

• Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder

  • study on Post-Traumatic Stress Disorder and Insomnia
  • open to healthy people ages 18-75

• Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

  • study on Cannabis and THC
  • open to healthy people ages 21-25

• Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study

  • study on Cataracts and Anesthesia
  • open to healthy people ages 60 years and up

• Cellular Aging and Neurobiology of Depression Study

  • study on Depression
  • open to healthy people ages 21-60

• Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

  • study on CADASIL and Dementia
  • open to healthy people ages 18 years and up

• ChangeGradients: Promoting Adolescent Health Behavior Change

  • study on Alcohol Use and Self Efficacy
  • open to healthy people ages 15-17

• Childhood Cancer Survivor Study

  • study on Cancer, General
  • open to healthy people

• Clinical and Biological Characteristics of Hidradenitis Suppurativa

  • study on Hidradenitis Suppurativa
  • open to healthy people ages 13 years and up

• Collaborative Approach to Examining Adversity and Building Resilience Study

  • study on Life Adversity and Caregivers
  • open to healthy people ages 2 years and up

• Collection of Blood for Multiple Collaborative Studies

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Comprehensive HHT Outcomes Registry of the United States (CHORUS)

  • study on Telangiectasia and Arteriovenous Malformation
  • open to healthy people

• CONNECTing to LungCare

  • study on Smoking Cessation and Carcinoma
  • open to healthy people ages 18 years and up

• Consent for Use of Stored Patient Specimens for Future Testing

  • study on HIV/AIDS
  • open to healthy people

• Cultural Adaptation of Drug Treatment for DJJ Youth

  • study on Substance Abuse
  • open to healthy people ages 12-17

• Dermatologic Research Evaluation and Monitoring of Sleep in Moderate-to-Severe Psoriasis

  • study on Psoriasis
  • open to healthy people ages 18 years and up

• Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults

  • study on Mild Cognitive Impairment and Meditation
  • open to healthy people ages 60-85

• Direct-to-patient Teledermatology and Computer-assisted Diagnosis

  • study on Telehealth
  • open to healthy people ages 18 years and up

• Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP

  • study on Sexually Transmitted Infections
  • open to healthy people ages 18 years and up

• Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health

  • study on Cancer, General
  • open to healthy people ages 18 years and up

• Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults

  • study on Loneliness and Neuroimaging
  • open to healthy people ages 60-120

• Effectiveness Study of Spironolactone Versus Doxycycline for Acne

  • study on Acne
  • open to healthy females ages 16-40

• Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

  • study on Depression
  • open to healthy people ages 18-65

• Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

  • study on Premature Birth and Early Labor
  • open to healthy females

• Enhancing Attention and Wellbeing Using Digital Therapeutics

  • study on Mild Cognitive Impairment and Cognitive Decline
  • open to healthy people ages 60-99

• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• Excipient Effect on Drug Absorption in Humans

  • study on Excipients
  • open to healthy people ages 18-64

• Expanding Fertility Care to Poor and Low Resourced Settings Study

  • study on Infertility
  • open to healthy males ages 18-64

• EyeConic: Qualification for Cone-Optogenetics

  • study on Retinal Dystrophy
  • open to healthy people

• Family Mental Health Family Navigator Project (FMHN)

  • study on Mental Health
  • open to healthy people ages 6-17

• Fecal Microbiota Transplant National Registry

  • study on Fecal Microbiota Transplant
  • open to healthy people

• Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)

  • study on Hernia
  • open to healthy females ages 18 years and up

• Fiber and Calcium Absorption in Older Men

  • open to healthy males ages 60 years and up

• First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia

  • study on Alzheimer's Disease and Dementia
  • open to healthy people ages 40-75

• Genomic Sequencing in Anatomically Normal Fetuses

  • open to healthy people ages 18-64

• Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome

  • study on Polycystic Ovary Syndrome and Insulin Resistance
  • open to healthy females ages 18-45

• Guselkumab Immunogenetics

  • study on Psoriasis and Guttate Psoriasis
  • open to healthy people ages 18 years and up

• Heart Rhythm Twins Study

  • study on Atrial Complex and Premature Ventricular Contractions
  • open to healthy people ages 18 years and up

• High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors

  • study on Leukemia and Acute Lymphoblastic Leukemia
  • open to healthy people ages 6 years and up

• Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver Disease

  • study on Liver Disease and Nonalcoholic Fatty Liver Disease
  • open to healthy people ages 18 years and up

• Immune Spatial Features of Guselkumab Cutaneous Response

  • study on Psoriasis
  • open to healthy people ages 18 years and up

• Implementation of COMPRENDO

  • study on Cancer, General
  • open to healthy people ages 18 years and up

• IMProving Adherence to Colonoscopy Through Teams and Technology

  • study on Colon Cancer and Colorectal Cancer
  • open to healthy people ages 18 years and up

• Inflammation, Diabetes, Ethnicity and Obesity Cohort

  • study on Obesity and Diabetes
  • open to healthy people ages 18-75

• Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers

  • study on Psilocybin
  • open to healthy people ages 21-70

• Intravenous Tranexamic Acid in Gender Affirming Mastectomy

  • study on Postoperative Hematoma and Postoperative Seroma
  • open to healthy females ages 18 years and up

• KIDney Injury in Times of COVID-19 (KIDCOV)

  • study on COVID-19 and Acute Kidney Injury
  • open to healthy people ages 18 years and up

• Lemborexant in Delayed Sleep Phase Syndrome

  • study on Delayed Sleep Phase and Sleep Disorders
  • open to healthy people ages 18 years and up

• Longitudinal Early-onset Alzheimer's Disease Study Protocol

  • study on Alzheimer's Disease and Mild Cognitive Impairment
  • open to healthy people ages 40-64

• Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome

  • study on Sturge-Weber Syndrome
  • open to healthy people

• Lymph Node Biopsies to Support HIV Pathogenesis Studies

  • study on HIV/AIDS
  • open to healthy people ages 18-70

• MARY-JANE Cannabis and Heart Rhythm Trial

  • study on Atrial Contractions and Premature Ventricular Contractions
  • open to healthy people ages 21 years and up

• Mechanistic Insights From Bronchoscopy Airway Samples

  • study on Asthma
  • open to healthy people ages 18-70

• Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

  • study on Schizophrenia
  • open to healthy people ages 18-64

• Metabolic Health Improvement Program: Effects of a Workplace Sugary Beverages Sales Ban and Motivational Counseling

  • study on Obesity and Insulin Resistance
  • open to healthy people ages 18 years and up

• Mindful Motivation for Reducing Binge Eating

  • study on Binge Eating Disorder and Health Behavior
  • open to healthy people ages 18 years and up

• Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care

  • study on Cancer, General and Hematopoietic and Lymphoid Cell Neoplasm
  • open to healthy people

• MRgFUS Versus CTgRFA for Osteoid Osteomas

  • study on Osteoid Osteoma
  • open to healthy people ages 8 years and up

• Multidisciplinary Low-Barrier and Mobile HIV Care to Improve Retention and Viral Suppression: Stakeholder-Engaged Design and Evaluation

  • study on HIV/AIDS
  • open to healthy people ages 15 years and up

• Music Improvisation Training on Cognitive Function in Older Adults

  • study on Cognitive Aging and Cognitive Impairment
  • open to healthy people ages 60 years and up

• Music, Social Attention, and Dementia

  • study on Dementia and Frontotemporal Dementia
  • open to healthy people ages 55-89

• Naltrexone for Overdose Prevention

  • study on Overdose Accidental and HIV/AIDS
  • open to healthy people ages 18 years and up

• Near Infrared Spectroscopy (NIRS) for Assessment of Depression

  • study on Depression
  • open to healthy people ages 18 years and up

• Neural and Cognitive Consequences of COVID-19 Survival

  • study on COVID-19 and Brain Fog
  • open to healthy people ages 18-70

• Neural and Physiological Correlates of Psychedelic Sub-states

  • study on Psychedelic Experiences and Neuroimaging
  • open to healthy people ages 21-70

• Neuroimaging Biomarkers for Predicting rTMS Response in OCD

  • study on Obsessive-Compulsive Disorder and Neuroimaging
  • open to healthy people ages 18-80

• Pancreatic Cancer Early Detection Consortium

  • study on Pancreatic Cancer and Pancreatic Cyst
  • open to healthy people ages 18-90

• Pancreatic Cancer Screening

  • study on Pancreatic Cancer and Cancer, General
  • open to healthy people ages 18 years and up

• Parathyroid Tumor Clonal Status

  • study on Parathyroid Tumor and Primary Hyperparathyroidism
  • open to healthy females ages 18-80

• Parenting Stress mHealth

  • study on Mental Health and Stress
  • open to healthy people ages 12 years and up

• Parkinson Progression Marker Initiative Online (PPMI Online)

  • study on Parkinson's Disease
  • open to healthy people ages 18 years and up

• Patient-centered Information on Permanent Contraception

  • study on Contraception and Reproductive Behavior
  • open to healthy females ages 21-45

• PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy

  • study on Lymphoma and Non-Hodgkin Lymphoma
  • open to healthy people ages 18 years and up

• Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

  • study on Nicotine and Tobacco
  • open to healthy people ages 21-70

• Pharmacodynamics of Synthetic Nicotine

  • study on Nicotine and Vaping
  • open to healthy people ages 21-65

• Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis

  • study on Parkinson's Disease and Psychotic Disorders
  • open to healthy people ages 40 years and up

• PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

  • study on Amyotropic Lateral Sclerosis (ALS) and Parkinson's Disease
  • open to healthy people ages 18-80

• Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis

  • study on Androgen Insensitivity Syndrome and Scoliosis
  • open to healthy people ages 10-18

• PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

  • study on Parkinson's Disease
  • open to healthy people ages 30 years and up

• Precision Dosing of Metformin in Youth With T2D

  • study on Diabetes and Diabetes Type 2
  • open to healthy people ages 10-21

• Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

  • study on Multiple Sclerosis and Clinically Isolated Syndrome
  • open to healthy females ages 18-64

• PrEP Point-of-Care Brief-Intervention for Adherence Among Young Men Who Have Sex With Men

  • study on PrEP
  • open to healthy males ages 18-30

• Prescription of Letrozole for Uterine Myoma

  • study on Uterine Fibroids and Leiomyoma
  • open to healthy females ages 21-53

• Pulse Oximeter Accuracy in Healthy Humans During Hypoxia

  • study on Hypoxia and Skin Pigmentation
  • open to healthy people ages 21-50

• Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

  • study on Opioid Use and Pupillary Miosis
  • open to healthy people ages 40-60

• Reaching for Equity in Sleep Apnea Treatment (REST) Study

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 18 years and up

• Repeated Low-level Red-light Therapy in Myopia Control

  • study on Myopia
  • open to healthy people ages 8-13

• Research on Equity in Abortion Care by TeleHealth

  • study on Abortion
  • open to healthy people ages 14-64

• Resilience Clinic Evaluation

  • study on Life Adversity and Caregivers
  • open to healthy people ages 2-5

• Response to Acute Exercise in Eating Disorders

  • study on Eating Disorders
  • open to healthy females ages 16-25

• Retinal Imaging in Patients With Inherited Retinal Degenerations

  • study on Retinitis Pigmentosa
  • open to healthy people ages 13 years and up

• Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

  • study on Depression and Attempted Suicide
  • open to healthy people ages 18-70

• Role of Transposable Elements in Septic Immune Aging

  • study on Sepsis and Sepsis and Septic Shock
  • open to healthy people ages 18 years and up

• Silver Lining in the VAD Sky

  • study on Driveline Infections
  • open to healthy people ages 18 years and up

• Skin Barrier Function and Inflammation in Aging: The BIA Study

  • study on Inflammation and Skin Inflammation
  • open to healthy people ages 70 years and up

• Smoke-free Home Study in Subsidized Housing

  • study on Tobacco and Smoking Cessation
  • open to healthy people ages 18 years and up

• Smoking Cessation CM for Veterans With or at Risk for Cancer

  • study on Tobacco and Substance Abuse
  • open to healthy people ages 18 years and up

• Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

  • study on Caesarean Section and Anesthesia
  • open to healthy females ages 15-55

• SPIROMICS Study of Early COPD Progression (SOURCE)

  • study on Chronic Obstructive Pulmonary Disease
  • open to healthy people ages 30-55

• SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)

  • study on Sphingolipidoses and Enzyme Deficiency
  • open to healthy people

• Systemic Valacyclovir (Valtrex) on Periodontitis

  • study on Periodontitis
  • open to healthy people ages 18-80

• Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain

  • study on Back Pain and Lower Back Pain
  • open to healthy people ages 21-85

• TReating Incontinence for Underlying Mental and Physical Health

  • study on Urinary Incontinence and Overactive Bladder
  • open to healthy females ages 60 years and up

• TrialNet Pathway to Prevention of T1D

  • study on Diabetes and Diabetes Type 1
  • open to healthy people ages 2-45

• UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

  • study on Ureteral Stone
  • open to healthy people ages 18 years and up

• Valacyclovir in Pain Management of Acute Apical Abscesses

  • study on Apical Abscess and Pain
  • open to healthy people ages 18-80

• Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

  • study on Stroke and Ischemic Stroke
  • open to healthy people ages 18 years and up

• Venlafaxine in Reducing Pain in Primary Total Knee Replacement

  • study on Pain and Knee Pain
  • open to healthy people ages 18-75

• VR for Pediatric Renal Biopsies

  • study on Procedural Pain and Procedural Anxiety
  • open to healthy people ages 5-17

• Wayfinding Intervention and Long-Term Memory

  • study on Long-Term Memory Decline and Mild Cognitive Impairment
  • open to healthy people ages 60-85

• Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

  • study on Breast Cancer and Cancer, General
  • open to healthy females ages 30-74

Current as of: May 5, 2025