Summary

Eligibility
for people ages 21-60 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
completion around
Principal Investigator
by Owen Wolkowitz, MDRyan Rampersaud, MD, PhD
Headshot of Owen Wolkowitz
Owen Wolkowitz

Description

Summary

We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences relate to memory performance, mood, and neurobiology. We are also interested in how the gut microbiome is affected by antidepressant treatment.

We will do this by comparing the unmedicated depressed patients with matched healthy controls at baseline and then following the depressed patients over the course of eight weeks of standardized antidepressant treatment to gauge which baseline abnormalities normalize over the course of treatment.

Official Title

Neurosteroid Metabolism and the Antidepressant Effects of Serotonin Specific Reuptake Inhibitors (SSRI's)

Details

Keywords

Major Depressive Disorder, MDD, Neurobiology, Selective Serotonin Reuptake Inhibitor, SSRI, Depression, Depressive Disorder

Eligibility

Location

  • UCSF accepting new patients
    San Francisco California 94143-0984 United States

Lead Scientists at UCSF

  • Owen Wolkowitz, MD
    Dr. Owen Wolkowitz is a clinical and translational research psychiatrist and Professor of Psychiatry at the University of California, San Francisco. His clinical work, teaching and research all focus on affective and anxiety disorders.
  • Ryan Rampersaud, MD, PhD
    Assistant Professor, Psychiatry, School of Medicine. Authored (or co-authored) 23 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
Links
Cellular Aging and Neurobiology of Depression (CAN-D) Study website
ID
NCT00285935
Study Type
Interventional
Participants
Expecting 228 study participants
Last Updated