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Nicotine Dependence clinical trials at UCSF
3 in progress, 1 open to new patients

  • Clinical Pharmacology of Electronic Cigarettes

    open to eligible people ages 21 years and up

    The purpose of this study is to learn more about nicotine exposure and the safety of electronic cigarettes (EC). It will focus on the areas that are thought to most closely relate to the addictive potential of EC, namely: (1) EC as nicotine delivery devices, covering issues of nicotine intake and pharmacokinetics, temporal patterns of use and titration of nicotine; and (2) subjective effects of EC use, including relationship of use to reward, withdrawal and craving.

    San Francisco, California and other locations

  • Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

    Sorry, not yet accepting patients

    This project will examine the impact of very low nicotine content (VLNC) cigarettes in a complex tobacco and nicotine product marketplace. We will compare the number of cigarettes smoked, use of alternative nicotine-containing products, biomarkers of toxicant exposure and days abstinence from cigarettes in an experimental marketplace that contains VLNC cigarettes versus normal nicotine content (NNC) cigarettes.

  • Project 2: Strategies for Reducing Nicotine Content in Cigarettes

    Sorry, in progress, not accepting new patients

    The main goal of this project is to compare two different approaches to reducing levels of nicotine in cigarettes: an immediate reduction in nicotine content in cigarettes to non-addictive levels or a gradual reduction in nicotine content in cigarettes to non-addictive levels. These two approaches will then be contrasted to a group that continues to smoke cigarettes with nicotine content similar to conventional cigarettes.

    San Francisco, California and other locations