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Plexiform Neurofibroma clinical trials at UCSF
1 in progress, 0 open to new patients

  • Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

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    This is a phase II open label study that will evaluate children ≥ 1 year of age and adults with neurofibromatosis type 1 (NF1) and plexiform neurofibromas treated with the MEK inhibitor, binimetinib. The primary objective is to determine if there is an adequate level of disease responsiveness to binimetinib in children and adults with NF1 and inoperable plexiform neurofibromas. The objective response to binimetinib is defined as ≥ 20% decrease in tumor volume reduction by 12 courses.

    Oakland, California and other locations